RELEVANCE OF EDUCATIONAL INFORMATION ABOUT THE RISK OF DRUG ALLERGIC REACTIONS
DOI:
https://doi.org/10.11603/me.2414-5998.2020.3.11450Keywords:
medicines, allergic reactions, cross-allergic reactionsAbstract
Increased morbidity worldwide causes the raising of drug consumption. Unfortunately, the risks sometimes could prevail the benefits. The known tendency today is the increasing to drug sensitivity. Allergic reactions or drug hypersensitivity are the most common drugs effects which are registered at hospitals and ambulatories of Ukraine. It could be provoked by any drug, even if patient never took it earlier. Risks are much higher in case of ignoring the possible cross-reactivity reactions. That is why the information about risks of allergic reactions in highly-sensitive people is extremely important in teaching the pharmacology. The questions of clinical signs and frequency of cases of drug allergic reactions to beta-lactam antibiotics, sulfonamides, nitrofurans are highlighted in the article. You will find international names of drugs which are registered in Ukraine. The ways of prevention of allergic reactions are pointed. It is important to collect the pharmacological anamnesis, to find out the information about food allergies, allergic diseases for each patient. Combined drug should be prescribed with cautions and after checking its components’ chemical structure. It is important to make diagnostic in vitro and in vivo tests if you have any doubts. Alertness of students in prescribing drugs is an essential skill which could effectively prevent negative outcomes of pharmacotherapy, especially drug allergic reactions.
References
Andreeva, I.V., & Stecyuk, O.U. (2013). Allergicheskie reaktsii na antibiotiki [Allergic reactions to antibiotics]. Klin. farmakologiya i terapiya – Сlin. Pharmacology and Therapy, 2 (22), 5-10 [in Russian].
Demchuk, A.V. (2015). Alerhіia na antybіotyky: mіfy tareapіi [Allergy to antibiotics: myths and realities]. Astma ta alerhіia – Asthma and Allergies, 1, 31-38 [in Ukrainian].
Zaikov, S.V., & Dmitrіeva, E.M. (2010). Lіkarska alerhіia pry anestezіolohіchnykh vtruchanniakh [Drug allergy during anesthesia]. Novosti meditsyny i farmatsii – Medicine and Pharmacy News, 11-12 (331-332) [in Ukrainian].
Luss, L.V. (2009). Problemy diagnostiki i profilaktiki lekarstvennoy allergii k mestnym anestetikam [Problems of diagnosis and prevention of drug allergy to local anesthetics]. Allergologiya, immunologiya, pulmonologiya – Allergology, Immunology, Pulmonology, 3 (35), 32-36 [in Russian].
Posohova, K.A. (2016). Perehresnі alerhіchnі reaktsіi na sulfopohіdnі: mіfy і realіi [Cross-allergic reactions to sulfoderivatives: myths and realities]. Ratsіonalna farmakoterapіia – Rational Pharmacotherapy, 1 (38), 13-19 [in Ukrainian].
The Order of the Ministry of Health of Ukraine of September 26, 2016 No.996 “On introduction of changes to some Orders of the Ministry of Health of Ukraine” [in Ukrainian].
The Order of the Ministry of Health of Ukraine of December 27, 2006 No. 898 “About Approval of Procedure for Surveillance over Adverse Reactions to Medicinal Products Permitted for Medical Use” [in Ukrainian].
Puhlik, B.M. (2010). Allergicheskie perekrestki [Allergic crossroads]. Novosti meditsiny i farmatsii – News of Medicine and Pharmacy, 21 (349) [inRussian].
Strom, B.L., Schinnar, R., Apter, A.J., Margolis, D.J., Lautenbach, E., Hennessy, S., Bilker, W.B., & Pettitt, D. (2003). Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics. N. Engl. J. Med., 349, 1628-1635. DOI: https://doi.org/10.1056/NEJMoa022963
Klauw, M., Wilson, J., & Stricker, B. (1996). Drug-associated anaphylaxis: 20 years of reporting in the Netherlands (1974-1994) and review of the literature. Clin. Exp. Allergy, 26, 1355-1363. DOI: https://doi.org/10.1111/j.1365-2222.1996.tb00536.x
Ponka, D. (2006). Approach to managing patients with sulfaallergy. Can. Fam. Physician, 52 (11), 1434-1438.
Prematta, T., Shah, S., & Ishmael, F.T. (2012). Physician approaches to beta-lactamuse in patients with penicillin hypersensitivity. Allergy Asthma Proc., 33 (2), 145-151. DOI: https://doi.org/10.2500/aap.2012.33.3526