MODERN STATE OF CREATION, PRODUCTION AND RESEARCH OF TABLET DRUGS Notice 28. Characteristics of the manufacturing process and research multi-layer tablets
DOI:
https://doi.org/10.11603/2312-0967.2018.2.9005Keywords:
multi-layer tablets, compatibility, immediate and slow release layer, disintegrants, polymers, release kinetics.Abstract
The aim of the work. Analyzing and systematizing the literature on technology, research methods and quality indicators of multi-layer tablets.
Materials and Methods. The methods of information retrieval, analysis of the literature on the dosage form – multi-layer tablets, were used in the study.
Results and Discussion. In the work data of literature on reception of multi-layer tablets is collected, their composition and technology are analyzed. Explains the main provisions for creating multi-layer tablets, which include advantages, disadvantages, different types of technology and tablet machines. The examples give a description of the composition of the layers of immediate and slow release, and the features of the methods for preparing tablet masses are shown. The characteristics of the evaluation of a bilayer tablet and factors influencing the release kinetics are distinguished.
Conclusions. Multi-layer tablets are new drug delivery systems in which substances with different release profiles are combined in one dosage form. To improve the release profiles, add disintegrants to the immediate release layer. The slow release layer includes a matrix polymer. There are different technologies for double-layer tablets. In order to obtain two-layer tablets, two powder mixtures are prepared separately using direct compression and/or granulation methods. The formation of multi-layer tablets is due to the progressive compression of individual powders on rotary tablet presses. Different types of multi-layer tablet machines are available on the market. Multi-layer tablets are evaluated by shape and size, height, crushing resistance, abrasion, homogeneity, dissolution, water absorption, quantitative content etc.
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