APPLICATION OF EXPERIMENTAL DESIGN METHOD IN OPTIMIZATION OF COMPOSITION AND TECHNOLOGY FOR MATRIX TABLETS CONTAINING VACCINIUM MYRTILLUS LEAF DRY EXTRACT
DOI:
https://doi.org/10.11603/2312-0967.2018.2.9003Keywords:
Vaccinium myrtillus leaf dry extract, matrix tablets, wet granulation method, experimental design.Abstract
The aim of the work. Studying the impact of the qualitative factors such as binder nature, moisture content and fractional composition, on the pharmaco-technological parameters of granulated tableting masses and matrix tablets containing Vaccinium myrtillus leaf dry extract.
Materials and Methods. The impact of the investigated factors was determined by tableting mass bulk and tapped densities, the Carr index and tablet crushing strength. All tests were performed according to the State Pharmacopoeia of Ukraine. Interpretation of the research data was carried out based on a dispersion analysis.
Results and Discussion. Using a three-factor dispersion analysis method it was found that binder nature significantly affects all the pharmaco-technological parameters studied, while moisture content is significant only for tablet crushing strength, and the fractional composition – only for bulk density of tableting mass.
Conclusions. On the basis of the studies conducted the following optimal parameters for the manufacturing of matrix tablets containing Vaccinium myrtillus leaf dry extract by wet granulation method were established: the use of 15 % solution of Plasdone S-630 copovidone as a granulating fluid; a residual moisture content of the tableting mass – (4.5±0.1) %; a fractional composition of the tableting mass – a mixture of equal amounts of granules less than 0.5 mm and granules larger than 0.5 mm but less than 1.0 mm in size.References
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