MEDICATED CHEWING GUMS: PRESCRIPTION, TECHNOLOGY AND ANALYSIS
DOI:
https://doi.org/10.11603/2312-0967.2018.1.8700Keywords:
medicated chewing gums, purpose, advantages, disadvantages, technology, pharmaco-technological indicators, quality indicators.Abstract
The aim of the work. Analyzing and systematizing the literature on the purpose and classification of medicated chewinggums, their technology, research methods and quality indicators.
Materials and Methods. The methods of information retrieval, analysis of the literature on the medical form – medicated chewing gum, were used in the study.Results and Discussion. The medicated chewing gum is a convenient drug delivery system; it provides a high patient compliance. Three methods are used in the production of chewing gums: the traditional method (melting); the method of freezing, grinding and tableting; the direct compression method. Pharmacopoeial parameters of the gums quality are: description, identification, average mass, uniformity of mass, uniformity of content, dissolution, microbiological purity, quantitative determination. In the course of the development of composition and technology of medicated chewing gums, the set of pharmaco-technological indicators and test methods is significantly different from pharmacopeial one and comprises the definition of numerous organoleptic properties, the study of texture by instrumental methods.
Conclusions. The medicated chewing gums are a mobile drug delivery system that contains one or more active ingredients that are released by chewing. The methods and features of technology, pharmaco-technological indicators and quality indicators of the medicated chewing gum are presented. This dosage form has advantages over traditional drug delivery systems; is characterized by high compliance. Among the three established methods of the gums producing, the direct compression method is becoming ever more popular because of the development of ready chewing bases of industrial production.
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