EXPERIMENTAL JUSTIFICATION OF THE NASAL GEL’S COMPOSITION UNDER THE CONVENTIONAL NAME “PHYTORIN-PLUS”

Authors

  • I. A. Karpenko National University of Pharmacy
  • T. G. Yarnykh National University of Pharmacy
  • O. A. Rukhmakova National University of Pharmacy

DOI:

https://doi.org/10.11603/2312-0967.2018.1.8604

Keywords:

nasal gel, licorice, essential oils, composition, experimental substantiation.

Abstract

The aim of the work. The experimental justification of the nasal gel’s composition under the conventional name “Phytorin-plus”.

Materials and Methods. In order to determine the rational concentration of the extract of licorice root and essential oils of Eucalyptus and Siberian pine in the gel microbiological studies were conducted on the basis of the Department of Microbiology, Virology and Immunology of the National University of Pharmacy in the laboratory of microbiological and immunological studies by diffusion to agar using reference strains of microorganisms Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 885/653.

Studies of antiviral activity were carried out on the basis of the State Institution “InstituteofMicrobiologyand Immunology named by I. I. Mechnykov of the Academy of Medical Sciences of Ukraine”.

Results and Discussion. Based on the studies, the rational concentrations of active ingredients in the nasal gel “Phytorin -plus” were justified: extract of licorice root – 3 %, essential oil of Eucalyptus – 2 %, essential oil of Siberian pine – 1 %. The data obtained were confirmed with further experimental study of antimicrobial and antiviral properties of the finished dosage form.

Conclusions. The choice of the active substances of nasal gel under the conventional name “Phytorin –plus” for the treatment of rhinitis has been experimentally proved. Based on the data of the conducted microbiological studies, the concentrations of the extract of licorice root and essential oils in the composition of the medicinal preparation were grounded.

The presence of antiviral action of licorice root extract in relation to adenovirus was established for the first time. It was shown that the developed nasal gel is promising for further use in the therapy of rhinitis.

Author Biographies

I. A. Karpenko, National University of Pharmacy

postgraduate student, Drugs Technology Department, National University of Pharmacy

T. G. Yarnykh, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor, Honored Worker of Science and Technique of Ukraine, Laureate of the State Prize of Ukraine in Science and Technique, Head of Drugs Technology Department, National University of Pharmacy

O. A. Rukhmakova, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Associate Professor of Drugs Technology Department, National University of Pharmacy

References

Nenasheva NM. [Achieving control of allergic rhinitis with the help of stepwise therapy]. Effektivnaya farmakoterapiya. Pulmonologiya i otorinolaringologiya. 2015;1: 14-22. Russian.

Ozdoganoglu T, Songu M, Inancli HM. [Quality of life in allergic rhinitis]. Ther. Adv. Respir. Dis. 2012;6: 25-39.

Kosakovskiy AL, Gavrilenko YuV. [Allergic rhinitis: etiology, pathogenesis, clinical manifestations and pathogenetically based therapy]. Ukrainskyi medychnyi chasopys. Aktualni pytannia klinichnoi praktyky. 2013;6(98): 23-7. Ukrainian.

Zaikov SV, Kuznetsova LV, Osipova LS, Nazarenko AP. [Features of rhinitis in acute respiratory viral infections]. Ukrainskyi medychnyi chasopys. Aktualni pytannia klinichnoi praktyky. 2013;5(97): 14-7. Ukrainian.

Rukhmakova OA., Yarnykh TH. [Prospects for the use of licorice bare as an immunomodulatory agent in pediatrics]. Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky. 2014;1(14): 47-9. Ukrainian.

Dubinskaya VA, Polyakov NA, Efremov AA, Efremov EA. [Determination of the biological activity of essential oils with the help of biotest systems in vitro]. Khimiya rastitelnogo syrya. 2013;3: 149-53. Russian.

Patent to utility model No. 95890 Ukraine, IPC (2011) A61K36/48, А61Р31/12. Application of licorice root extract as an antiviral agent in relation to type 3 adenoviruses in pediatrics. Yarnykh TG, Rukhmakova OA, Panchenko LO; an application and patents. NFaU - No. u 201408184; stated. July 21, 14; has published 12.01.15; 1: 1-4.

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Published

2018-03-24

How to Cite

Karpenko, I. A., Yarnykh, T. G., & Rukhmakova, O. A. (2018). EXPERIMENTAL JUSTIFICATION OF THE NASAL GEL’S COMPOSITION UNDER THE CONVENTIONAL NAME “PHYTORIN-PLUS”. Pharmaceutical Review Farmacevtičnij časopis, (1), 29–33. https://doi.org/10.11603/2312-0967.2018.1.8604

Issue

No. 1 (2018)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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