STUDY ON TECHNOLOGY DEVELOPMENT OF "STIMUPHYT" TINCTURE INTENDED FOR TELOGEN EFFLUVIUM APPLICATION

Authors

  • M. I. Fedorovska Ivano-Frankivsk National Medical University
  • N. P. Polovko National University of Pharmacy
  • N. S. Leochko Ivano-Frankivsk National Medical University

DOI:

https://doi.org/10.11603/2312-0967.2018.1.8599

Keywords:

Telogen effluvium, tincture, Urtica dioica, Salvia officinalis, Aesculus hyppocastanum, technological parameters.

Abstract

The aim of the work. Technology development of "Stimuphyt" complex tincture which is intended for Telogen effluvium cutaneous treatment.

Materials and Ьethods. As plant raw materials (PRM) a following mixture was used: Urtica dioica leaves –50 g, Salvia officinalis leaves –30 g, Aesculus hyppocastanum leaves –20 g. Optimal extraction parameters were being chosen for the technology development of the complex tincture, namely: the concentration of ethanol (20% 40%, 70%), the ratio of PRM and obtained tincture (1:5, 1:10, 1:15, 1:20), sizes of PRM particles (cut and non- sifted PRM, different fractions), time (6 h, 1 day, 2 days, 3 days, 7 days) and the extraction methods (maceration, remaceration, percolation). The yield of dry residues and quantitative content of hydroxycinnamic acids (GCA) were used as the evaluation criteria.

Results and Discussion. 40 % ethanol was chosen as an extraction agent, because it dissolves the basic biologically active substances and is safe for cutaneous application. Taking into account the concentration of dry residues and GCA in the tincture and also in the dry PRM (recalculation of PRM extraction efficiency) the complex tincture technology was substantiated. Thus the tincture was obtained from cut and non- sifted mixture of PRM at a 1:10 ratio with the method of triple remaceration for 3 days.

Conclusions. The optimum technological parameters of the complex tincture preparation were determined, namely: the concentration of ethanol – 40 %, the ratio of PRM and obtained product – 1:10, sizes of PRM particles – cut and non- sifted PRM, extraction time – not longer than 3 days, the method of extraction – remaceration. Considering the obtained results, the technological scheme of "Stimuphyt" complex tincture preparation in industrial conditions was developed.

Author Biographies

M. I. Fedorovska, Ivano-Frankivsk National Medical University

Candidate of Pharmaceutical Sciences (PhD), Associate Professor, Organization and Economics in Pharmacy and Technology Department, Ivano-Frankivsk National Medical University

N. P. Polovko, National University of Pharmacy

Doctor of Sciences in Pharmacy, Professor, Drug Technology Department, National University of Pharmacy

N. S. Leochko, Ivano-Frankivsk National Medical University

Candidate of Technical Sciences (PhD), Associate Professor, Chemistry Department of Pharmaceutical Faculty, Ivano-Frankivsk National Medical University

References

Halliamova YuA. [The strategy and tactics of treating of diffuse hair thinning]. Lechashch vrach. 2012;10: 17-7. Russian.

Yarema IO, Fedorovska MI, Sokolova LV. [Marketing researche of medicinal and cosmetic products intended for use in various forms of alopecia]. Aktualni pytannia pharmatsevt med nauky praktyky. 2014;3: 106-10. Ukrainian.

Patil SM, Sapkale GN, Surwase US, Bhomble BT. [Herbal medicines as an effective therapy in hair loss – A review]. Res J Pharm Biol Chem Sci. 2010;1: 773-81.

Kaushik R, Gupta D, Yadav R. [Alopecia: herbal remedies]. Int J Pharm Sci Res. 2011;2(7): 1631-37.

Maloshtan LM, Bashura AO, Polovko NP, Strus OYe. [Investigation of the horse chestnut leaves tincture activity in order to develop the composition of medicinal and cosmetic products]. Aktualni pytan pharmatsevt med nauky praktyky. 2012;1: 71-3. Ukrainian.

Fedorovska MI. [Prospect of medicinal plants application in various forms of alopecia]. Fitoterap chasop. 2014;3: 73-7. Ukrainian.

State Pharmacopoeia of Ukraine: in 3 vol. / State Enterprise “Ukrainian Research Center expert pharmacopoeia quality medicines.” – 2nd ed. – Kharkiv State Enterprise “Ukrainian Research Center expert pharmacopoeia drug quality”. 2015; 1: 1128. Ukrainian.

Halkin OYu, Kotov AH. [Determination of the optimal parameters of technology of phytopreparation for treatment and prevention of different types of alopecia]. Farmatsevt chasop. 2011;1: 35-8. Ukrainian.

Downloads

Published

2018-03-24

How to Cite

Fedorovska, M. I., Polovko, N. P., & Leochko, N. S. (2018). STUDY ON TECHNOLOGY DEVELOPMENT OF "STIMUPHYT" TINCTURE INTENDED FOR TELOGEN EFFLUVIUM APPLICATION. Pharmaceutical Review Farmacevtičnij časopis, (1), 34–40. https://doi.org/10.11603/2312-0967.2018.1.8599

Issue

No. 1 (2018)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

License

The authors who publish their materials in this journal agree with the following terms:

  • Authors reserve the right to authorship of their work and assign to the journal the right to first publish this work under the terms of the Creative Commons Attribution License, which allows other persons to freely distribute the published work with a mandatory reference to the authors of original work and the first publication of work in this journal Результат пошуку зображень за запитом "CC-BY logo".
  • Authors have the right to make independent extra-exclusive work agreements in the form they are published by this journal (for example, posting work in an electronic repository of an institution or publishing as part of a monograph), provided that the link to the first publication of the work in this journal is maintained.

Journal policy allows and encourages publication of manuscripts on the Internet (for example, in institutions repositories or on personal websites), both before the publication of this manuscript and during its editorial review, as it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the citation of the published work (see The Effect of Open Access).