SELECTION OF EXCIPIENTS FOR L-TRIPTOPHANE TABLETS WITH THIOTRIAZOLINE BY WET GRANULATION
DOI:
https://doi.org/10.11603/2312-0967.2017.3.8118Keywords:
L-tryptophan, thiotriazoline, tablets, excipients, wet granulation method, the mathematical experiment planning.Abstract
The aim of the work.Creation of new tablet drug with neuropsychotropic effect based on L-tryptophan and thiotriazoline, selection of optimal excipients, study of their effect on the pressing process, surface quality and uniformity of the tablet dosing mass.
Materials and Methods.The active substances are L-tryptophan and thiotriazoline in a 4:1 ratio, excipients (fillers, disintegrants, binding solutions, solubilizers).The tablets were compressed by wet granulation.The effect of the excipients on tablets containing L-tryptophan and thiotriazoline was studied according to the following parameters: uniformity of the tablet dosing mass, pressing process, appearance of tablet surface after production.
Results and Discussion.According to the results of ANOVA of the experimental data, it was found that the nature of the fillers, disintegrants, binding solutions, solubilizers influences the pressing process, the appearance of the surface of the tablets after production, and the uniformity of the tablet dosing mass with L-tryptophan and thiotriazoline. For example, the mixture of such explosives as MCC 101+potato starch+neusilin UFL has the best influence among fillers on the process of tablets pressing, sodium starch glycolate is the leader among disintegrants.
The quality of the surface of L-tryptophan tablets with thiotriazoline after production is most favorably affected by the mixture of MCC 101+potato starch+basic magnesium carbonate among disintegrants. The 5% solution of hydroxypropymethylcellulose 5 is the leader for uniformity of the tablet dosing mass among binders, the advantage is on the side of the polyplasdone XL 10 among disintegrants, the mixture of MCC 101+potato starch+magnesium carbonate is the main one among the fillers, aerosil is the most influential among the solubilizers.
Results.The effect of four groups of excipients on the uniformity of dosing, the pressing process and the appearance of tablets with L-tryptophan and thiotriazoline was studied.Most of the 16 studied excipients are suitable for tableting based on L-tryptophan and thiotriazoline by wet granulation.The diagrams of the advantages of the levels of 4 investigated factors were made from the studied parameters (pressing process, surface quality of tablets, uniformity of dosing).
Conclusions. The rational selection of excipients to obtain tablets based on L-tryptophan and thiotriazoline by wet granulation method was carried out. The influence of excipients on uniformity of dosing, the pressing process and the appearance of L-tryptophan and thiotriazoline tablets obtained by wet granulation, was considered.
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