MODERN STATE OF CREATION, PRODUCTION AND RESEARCH OF FAST DISSOLVING ORAL FILMS
DOI:
https://doi.org/10.11603/2312-0967.2017.2.7907Keywords:
fast dissolving oral fi lm, mouth, technology of manufacturing, polymers.Abstract
The aim of the work. The literature data on the basic characteristics, features of technology, opportunities of use fast dissolving oral fiilms were studied and summarized.
Materials and Methods. Literature review of dosage form-fast dissolving oral film.
Results and Discussion. Fast dissolving oral fiilm is a very thin film with area of 5-20 cm2, which the patient can placed on the tongue or the mucous membrane in the mouth. Saliva, which wets the film, leads to rapid hydration and it adhesion to the place of use. Composition of fast dissolving oral films is consisting of active pharmaceutical ingredients, water-soluble polymers, plasticizers, sweeteners, flavors, saliva stimulating agents. The following processes can be used to manufacture the oral fast dissolving films: solvent casting method, semisolid casting, hot-melt extrusion method, rolling method. To evaluate the quality of films, mechanical properties, organoleptic characteristics, pH of film surface, transparency, uniformity of content, disintegration, dissolution, quantitative determination are determined.
Conclusions. The main characteristics, technology, and the possibility of using films those are capable of attaching to the oral mucosa rapidly releasing drugs were considered.References
Sastry SV, Nyshadham JR, Fix JA. Recent technological advances in oral drug delivery. A review. Pharm Sci Technol Today. 2000;3:138-145.
Bhupinder B, Sarita J, Mandeep K, Harmanpreet S. Orally fast dissolving fi lms: innovations in formulation and technology. Int J Pharm Sci Rev Res. 2011;9(2):50-7.
Deepak Heer, Geeta Aggarwal, SL Hari Kumar. Recent trends of fast dissolving drug delivery system - an overview of formulation technology. Pharmacophore. 2013;4(1):1-9.
Deepak Sharma, Daljit Kaur, Shivani Verma, Davinder Singh, Mandeep Singh, Gurmeet Singh, et al. Fast dissolving oral films technology: a recent trend for an innovative oral drug delivery system. Int J Drug Delivery. 2015;7(2):60-75.
Chonkar Ankita D, Bhagawati ST, Udupa N. An overview on fast dissolving oral films. Asian J Pharm Tech 2015;5(3):129-37. Available from: http://dx.doi.org/10.5958/2231-5713.2015.00020.3
Patel R, Prajapati S, Raval A. Fast dissolving films (FDFS) as a newer venture in fast dissolving dosage forms. Int J Drug Dev & Res. 2010;2(2):232-46.
Dhagla Ram Choudhary, Vishnu Patel, Harsha Patel, Aliasgar J Kundawala. Exploration of film forming properties of film formers used in the formulation of rapid dissolving films. Int J Chemtech Res. 2011;3(2): 531-33.
Hirpara Freny, Kumar Debnath Sujit, Saisivam S. Optimization & screening of different film forming polymers and plasticizers in fast dissolving sublingual film. Int J Pharm Pharm Sci. 2014;6(6):41-2.
Ankita Keshari, Pramod Kumar Sharma, Nayyar Parvez M. Fast dissolving oral film: a novel and innovative drug delivery system. Int J of Pharm Sci and Res. 2014;5(3):92-5.
Arun A, Chandra A, Sharma V, Pathak K. Fast dissolving oral fi lms: an innovative drug delivery system and dosage form. Int J Chemtech Res. 2010;2(1):576-83.
Alka Tomar, Kiran Sharma, Nitesh S Chauhan, Ashu Mittal, Umakant Bajaj. Formulation and evaluation of fast-dissolving oral film of Dicyclomine as potential route of buccal delivery. Int J Drug Dev & Res. 2012;4(2):408-17.
Sharma R, Parikh RK, Gohel MC, Soniwala MM. Development of taste masked film of valdecoxib for oral use. Indian J Pharm Sci. 2007;69(2):320-323.
Cilruzo F, Cupone EI, Minghetti P, Buratti S, Chiara G.M. Gennari, Montanari L. Diclofenac fast-dissolving film: suppression of bitterness by a taste-sensing system. Drug Dev Ind Pharm. 2011;37(3):252-59. Available from: http:// dx.doi.org/10.3109/03639045.2010.505928
Gavaskar Basani, Kumar Subash Vijaya, Guru Sharan, Rao Y Madhusudan. Overview on fast dissolving films. Int J Pharm Pharm Sci. 2009;2(3):2933.
Aggarwal Jyoti, Singh Gurpreet, Saini Seema, Rana AC. Fast dissolving oral films: a novel approach to oral drug delivery. Int Res J of Pharm. 2011;2(12):69-74.
Gunjan Shrivastava, Pankaj Kumar Singh, Roshni Fatima Rizvi, Shailendra Kumar Singh. A novel approach for buccal drug delivery system - fast dissolving fi lm. World Journal of Pharmacy and Pharmaceutical Sciences. 2015;4(10):1744-60.
Bhyan Bhupinder, Jangra Sarita. Formulation and evaluation of fast dissolving sublingual films of Rizatriptan Benzoate. Int J Drug Dev & Res. 2012;4(1):133-4.
Ali MS, Vijendar C, Kumar SD, Krishnaveni J. Formulation and evaluation of fast dissolving oral films of diazepam. J Pharmacovigilance. 2016;4(3):210.
Deepthi A, Venkateswara Reddy B, Navaneetha K. Formulation and evaluation of fast dissolving oral films of Zolmitriptan. American Journal of Advanced Drug Delivery. 2014;2(2):153-63.
Koland M, Sandeep VP, Charyulu NR. Fast dissolving sublingual films of ondansetron hydrochloride: effect of additives on in vitro drug release and mucosal permeation. J Young Pharm. 2010;2(3):216-22.
Hema Chaudhary, Samita Gauri, Permender Rathee, Vikash Kumar. Development and optimization of fast dissolving orodispersible films of granisetron HCl using Box-Behnken statistical design. Bulletin of Faculty of Pharmacy, Cairo University. 2013;51(2):193-201.
Hrynovets IS, Kalynyuk TH, Melnyk YuYa, Suberlyak OV. The study of deformation and mechanical properties of dental medical polymer type fi lm. Farmats. zhurnal. 2009;5: 123-8. Ukrainian.
Available from: http://www.in-pharmatechnologist.com/ Ingredients/BioProgress-uses-fi lms-in-drug-delivery
Prasanna Kumar Desu, B Brahmaiah, A Nagalakshmi, K Neelima, Sreekanth Nama, Chandu Baburao. An overview on rapid dissolving films. Asian J Pharm Res 2013;3(1):15-23.
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