ANALYSIS OF THE USE OF ANTIBACTERIAL DRUGS IN THE COMPLEX TREATMENT OF PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA
DOI:
https://doi.org/10.11603/2312-0967.2024.2.14700Keywords:
community-acquired pneumonia, clinical manifestations, dynamics of indicators, antibiotics, antibiotic therapy, effectiveness and safety of treatmentAbstract
The aim of the work. This study aimed to analyze the usage of various antibacterial drugs for community-acquired pneumonia (CAP) patients in a hospital setting and to evaluate the therapy clinically and pharmacologically.
Materials and Methods. The study examined the records of CAP patients treated at Ternopil City Communal Hospital No. 3. Statistical analysis of the data was performed using an Excel XP spreadsheets.
Results and Discussion. A retrospective analysis of the records showed that CAP was diagnosed in 21 (51.22%) men and 20 (48.78%) women, with patients’ ages ranging from 34 to 95 years (average age 57 years). The most common symptoms were cough, fever, and general weakness. Moreover, 29 patients (70.73%) had concomitant diseases affecting various body systems. Antibiotic therapy for CAP patients included treatment with cephalosporins (Ceftriaxone, Cefazolin) for 30 (or 73.17%) patients, fluoroquinolones (Levofloxacin) for 9 (or 21.95%) patients, and combined antibiotic (Augmentin) for 2 (or 4.88%) patients. The most commonly used drugs were Ceftriaxone, Cefazolin, and Levofloxacin. The use of these antibacterial drugs had a positive effect on the CAP patients' subjective and objective condition. All patients showed a disappearance of disease symptoms, and the laboratory and instrumental indicators of their health normalized.
Conclusions. The clinical and pharmacological analysis of antibacterial drugs used in the treatment of CAP patients at Ternopil City Communal Hospital No. 3 demonstrated a positive effect on their key clinical, laboratory, and instrumental indicators.
References
Adapted evidence-based clinical practice. Unified protocol for providing medical care to adult patients with community-acquired pneumonia [Internet]. Available from: http://www.ifp.kiev.ua/doc/staff/pneumonia_guidelines_2016.pdf. Ukrainian.
Kovalenko NI, Zamazii TM, Novikova IV. Analysis of antibiotic resistance of opportunistic microflora isolated from community-acquired pneumonia. Infectious diseases. 2020; 3:44-49. [in Ukrainian].
World Health Statistics – 2019. Geneva: World Health Organization, 2019. P. 120 [Internet]. Available from: https://www.who.int/publications/i/item/9789241565707.
Aliberti S, Dela Cruz, CS, Amati F, Sotgiu G, Restrepo MI. Community-acquired pneumonia. Lancet. 2021;398: 906–919.
Candel FJ, Salavert M, Basaras M, Borges M, Cantón R et al. Ten Issues for Updating in Community-Acquired Pneumonia: An Expert Review. Journal of clinical medicine. 2023; 12(21): 6864. doi.org/10.3390/jcm12216864
Cavallazzi R, Ramirez, JA. How and when to manage respiratory infections out of hospital. European respiratory review: an official journal of the European Respiratory Society. 2022;31(166): 220092. doi.org/10.1183/16000617.0092-2022
State Statistics Service of Ukraine [Internet]. Available from: http://www.ukrstat.gov.ua/druk/publicat/kat_u/publ11_u.htm.
Cillóniz C, Rodríguez-Hurtado D, Torres, A. Characteristics and management of community-acquired pneumonia in the era of global aging. Medical Sciences. 2018; 6(2):35.
Mostovoi YM. Nosocomial pneumonia: key provisions of diagnosis and treatment. Ukr. Med. Journal. 2016;1(111): 49–51. [in Ukrainian].
Community-acquired pneumonia in adults: etiology, pathogenesis, classification, diagnosis, antimicrobial therapy and prevention. Adapted evidence-based clinical practice. [Internet]. Available from: http://www.ifp.kiev.ua/ftp1/metoddoc/Pneumonia_guidelines_2019_[rev29].pdf. Ukrainian.
Solovyov O. A modern approach to the treatment of community-acquired pneumonia. Medical newspaper "Health of Ukraine of the 21st Century". 2022; 18-19: 535-536. [in Ukrainian].
Snegyrev FG. Nosocomial pneumonia in adults: etiology, pathogenesis, classification, diagnosis, antimicrobial therapy and prevention. Ukrainian medical journal. [Internet]. Available from: https://umj.com.ua/uk/novyna-157209-negospitalna-pnevmoniya-u-doroslih-osib-etiologiya-patogenez-klasifikatsiya-diagnostika-antimikrobna-terapiya-ta-profilaktika-adaptovana-klinichna- nastanova-zasnovana-na-dokazah-namn-ukrayini-2019. Ukrainian.
Sheiko SO, Kolb NO. Teaching pneumonia at the "General practice-family medicine" specialization cycle. Galician Medical Herald. 2017; 24(1): 46-48. [in Ukrainian].
Instruction 00122. Pneumonia. [Internet]. Available from: https://guidelines.moz.gov.ua/documents/3023. [in Ukrainian].
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Pharmaceutical Review / Farmacevtičnij časopis
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The authors who publish their materials in this journal agree with the following terms:
- Authors reserve the right to authorship of their work and assign to the journal the right to first publish this work under the terms of the Creative Commons Attribution License, which allows other persons to freely distribute the published work with a mandatory reference to the authors of original work and the first publication of work in this journal
. - Authors have the right to make independent extra-exclusive work agreements in the form they are published by this journal (for example, posting work in an electronic repository of an institution or publishing as part of a monograph), provided that the link to the first publication of the work in this journal is maintained.
Journal policy allows and encourages publication of manuscripts on the Internet (for example, in institutions repositories or on personal websites), both before the publication of this manuscript and during its editorial review, as it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the citation of the published work (see The Effect of Open Access).
