ALGORITHM FOR DIAGNOSIS OF ERYTHEMA MIGRANS IN CHILDREN

Authors

  • S. O. Nykytyuk I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/1681-2727.2018.4.9771

Keywords:

Lyme borreliosis, Borelia, children, Erythema migrans, diagnosis, ticks, questionnaire

Abstract

The aim of the work – to establish the preconditions and the frequency of natural infection of B. burgdorferi sensu lato with mites selected after the bite of children in Ternopil region in different months of the year, as well as to determine the preventive methods for controlling the tick bites in children.

Materials and Methods. 291 children after mite bite were examined, All responded to the question of the Unified International Questionnaire. In the laboratory of the medical university, during July-October 2017, 169 mites taken from the skin of children were examined. Real-time PCR method was used, a two-stage serological examination was performed: ELISA screening test for the presence of IgM / IgG antibodies, Western blot.

Results. Lyme disease is manifested in many clinical forms. The younger the child, the more difficult it is to diagnose Lyme’s disease.

Conclusions. The high incidence of Lyme borreliosis cases among urban residents was noted (92.8 %). In 38.3 % of the patients from the moment of the tick bite to its removing more than 24 hours passed. Cases of the disease on Lime borellosis were registered for almost a year, with peaks in July and October. 58.0 % of ticks were infected. The presence of a contact with the mites affected by B. burgdorferi and the occurrence of a patient migrating with erythema (ME) is sufficient to diagnose Lyme’s disease and start treatment. With the help of two-stage serologic diagnosis, it was possible to detect antibodies to Borrelia burgdorferi sensu lato in 52.0 % of the examined children.

References

Stanek, G., Wormser, G.P., Gray, J., & Strle, F. (2012). Lyme borreliosis. Lancet, 379 (9814), 461-473.

Susanna Esposito, Samantha Bosis, Caterina Sabatini, Laura Tagliaferri, & Nicola Principi (2013). Borrelia burgdorferi infection and Lyme disease in children. International Journal of Infectious Diseases, 17 (3), 153-158.

Shkilna, M.I. (2016). Laim-borelioz u pratsivnykiv lisovykh hospodarstv Ternopilskoi oblasti [Lime Borellios in the forestry workers of the Ternopil region]. Infektsiini khvoroby – Infectious Diseases, 1 (83), 36-40 [in Ukrainian].

Weber, K. (2001). Aspects of Lyme borreliosis in Europe. European Journal of Clinical Microbiology & Infectious Diseases, 20 (1), 6-13.

(2010). Tsentralizovannaya informatsyonnaya sistema po infektsyonnym zabolevaniyam Yevropeyskogo regionarnogo byuro VOZ [Centralized information system for infectious diseases WHO European Regional Office]. Retrieved from: http://data.euro.who.int/cisid. [in Russian].

Bartosik, K., Kubrak, T., Olszewski, T., Jung, M., & Buczek, A. (2008). Prevention of tick bites and protection against tick-borne diseases in south-eastern Poland. Annals of Agricultural and Environmental Medicine, 15 (2), 181-185.

Centers for Disease Control and Prevention. Reported Cases of Lyme Disease by Year, United States, 2002-2011; 2012 Sept 12 [cited 2013 Mar 24]. Retrieved from: http://www.cdc.gov/lyme/stats/chartstables/casesbyyear.html

Dryden, M.S., Saeed, K., Ogborn, S., & Swales, P. (2015). Lyme borreliosis in southern United Kingdom and a case for a new syndrome, chronic arthropod-borne neuropathy. Epidemiology and Infection, 143 (3), 561-572.

Philip S.S. (2013). Current Medical Diagnosis and Treatment. New York: McGraw-Hill. Spirochetal Infections. Retrieved from: http://www.accessmedicine.com.eres.library.manoa.hawaii.edu/content.aspx?aID=18802&searchStr=lyme+disease

Caulfield, A.J., & Pritt, B.S. (2015). Lyme disease coinfections in the United States. Clin. Lab. Med., 35 (4), 827-846.

Wilking, H., & Stark, K. (2014). Trends in surveillance data of human Lyme borreliosis from six federal states in eastern Germany. Ticks and Tick-borne Diseases, 5 (3), 219-224.

Berglund, J., Eitrem, R., Ornstein, K., Lindberg, A., Ringer, A., Elmrud, H., Carlsson, M. (1995). An epidemiologic study of Lyme disease in southern Sweden. English Medical Journal, 333 (20), 319-1327.

Fingerle, V., Schulte-Spechtel, U.C., Ruzic-Sabljic, E., Leonhard, S., Hofmann, H., Weber, K., & Pfister, K. (2008). Epidemiological aspects and molecular characterization of Borrelia burgdorferi s.l. from southern Germany with special respect to the new species Borrelia spielmanii sp. nov. International Journal of Medical Microbiology, 298 (3-4), 279-290.

Steer, A.C. Lyme borreliosis. Harrison’s Infectious Diseases. Casper, D.L. & Fauci, A.S. (Eds.). 670-676.

Stanek, G., & Reiter, M. (2011). The expanding Lyme Borrelia complex – clinical significance of genomic species? Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria. Retrieved from: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1469-0691.2011.03492.x

Balmelli, T., Piffaretti, J.C. (1995). Association between different clinical manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato. Research in Microbiology, 146 (4), 329-340.

Strle, F., Stanek, G. (2009). Clinical manifestations and diagnosis of lyme borreliosis. Current Problems in Dermatology, 37, 51-110.

Huppertz, H.I., Böhme, M., Standaert, S.M., Karch, H., & Plotkin, S.A. (1999). Incidence of Lyme borreliosis in the Würzburg region of Germany. European Journal of Clinical Microbiology and Infectional Diseases, 18 (10), 697-703.

Girschick, H.J., Morbach, H., & Tappe, D. (2009). Treatment of Lyme borreliosis. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003502/pdf/ar2853.pdf

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Published

2019-01-30

How to Cite

Nykytyuk, S. O. (2019). ALGORITHM FOR DIAGNOSIS OF ERYTHEMA MIGRANS IN CHILDREN. Infectious Diseases – Infektsiyni Khvoroby, (4), 15–19. https://doi.org/10.11603/1681-2727.2018.4.9771

Issue

No. 4 (2018)

Section

Original investigations

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Received 2019-01-30
Accepted 2019-01-30
Published 2019-01-30