ПОЛІМОРФІЗМ ГЕНІВ ПРИ ВІЛ-ІНФЕКЦІЇ

V. D. Moskaliuk; M. O. Andrushchak

doi:10.11603/1681-2727.2015.4.5521

Автор(и)

V. D. Moskaliuk
M. O. Andrushchak

DOI:

https://doi.org/10.11603/1681-2727.2015.4.5521

Анотація

Проаналізовано захворюваність на ВІЛ-інфекцію та дослідження поліморфізму генів. Особливу увагу приділено мутаціям з генотипом CCR5 ∆32 та CCR-2 варіант 64І, їх взаємозв’язку з іншими мутаціями, встановлено їхній вплив на перебіг ВІЛ-інфекції. З’ясовано вплив хемокінів, цитокінів та інтерлейкінів у ВІЛ-інфікованих на генний поліморфізм.

Ключові слова: ВІЛ-інфекція, поліморфізм генів, генотип, хемокіни, цитокіни.

Посилання

Література

Duesberg P.H. Infectious AIDS: Have We Been Misled? / P.H. Duesberg.  North Atlantic Books, Berkeley, California, 1995. – 582 r.

Duesberg P.H. Inventing the AIDS virus / P.H. Duesberg.  Regnery Publishing, Inc., D.C. Washington, 1996. – 723 p.

Sazonova Y.M. VYCh-SPYD «vyrtualnyi vyrus, yly provokatsyia veka» / Y.M. Sazonova. – M.: OOO «Yzd-vo «Olymp»: OOO «Yzd-vo ACT», 2003. – 365s.

Kuchmenko O.B. Problemy SNIDu v Ukraini ta metodyka podolannia / O.B. Kuchmenko // Problemy osvity. – 2006. – № 48. – S. 27-31.

Chornetska V.D. Deiaki medyko-biolohichni aspekty formuvannia u studentiv uiavlennia pro nebezpeku VIL/SNID / V.D. Chornetska // Problemy osvity. – 2006. – № 48. – S. 32-37.

Choba N.V. SNID – realii, profilaktyka, fizychna reabilitatsiia / N.V.Choba // Fizychne vykhovannia, sport i kultura zdorovia u suchasnomu suspilstvi: zb. nauk. prats.  2011. – №. 4 (16).  S. 82-86.

VIL-infektsiia v Ukraini. Inf. biuleten № 35.  K: MOZ Ukrainy, Inf. Tsentr profilaktyky i borotby zi SNIDom, 2011. – 62 s.

VYCh-ynfektsyia u detei / A.H. Rakhmanova, E.N. Vynohradova, E.E.Voronyn [y dr.] – SPb: Pyter, 2003. – 440 s.

VIL-infektsiia v Ukraini. Inf. biuleten № 44.  K: MOZ Ukrainy, Inf. Tsentr profilaktyky i borotby zi SNIDom, 2015. – 24 s.

Chakraborty R. HIV-1 infection in children: A clinical and immunologic overview / R. Chakraborty // Current HIV Research. – 2005. – Vol. 3. – P. 31-41.

Mortality in HIV-infected and uninfected children of HIVinfected and uninfected mothers in rural Uganda / H. Brahmbhatt, G. Kizogi, F. Wabwire-Mangen [et al.] // J Acquir Immune Defic. Syndr. – 2006. – Vol. 41, N 4. – P. 504-508.

Pattern of Pediatric HIV/AIDS: A Five-Year Experience in a Tertiary Hospital / B. Onankpa // J. Nat. Med. Ass. – 2008. – Vol. 100, N 7. – P. 56-60.

Zaplatyskyi V.M. Pytannia profilaktyky VIL/SNIDu u haluzevykh standartakh vyshchoi shkoly / V.M. Zaplatyskyi, V.D. Chornenka // Bezpeka zhyttia i diialnosti liudyny – osvita, nauka, praktyka. Materialy IV nauk.-metod. konf. K.: NAU, 2005. – S. 87-92.

Tyrkus M.Ia. Chastota mutatsii CCR2-64I hena khemokinovoho retseptora CCR2, shcho asotsiiuietsia z upovilnenniam prohresuvannia SNIDu, u zhyteliv Zakhidnoi Ukrainy / M.Ia. Tyrkus // Faktory eksperymentalnoi evoliutsii orhanizmiv. – 2013. – T. 13. – S. 334-338.

Kravchenko O.M. Subtypova struktura populiatsii VIL-1, shcho tsyrkuliuie na terytorii Ukrainy / O.M. Kravchenko, M.H Liulchuk, A.M. Shcherbinska // Ukr. zhurn. dermatovenerol., venerol., kosmetol. – 2002. – № 1. – S. 101-102.

Kozlov A.P. VYCh v Rossyy, Belorussyy y na Ukrayne / A.P. Kozlov // Rus. zhurn. VYCh/SPYD y rodstvennye problemy. – 2000. – T. 4, № 1. – S. 11-14.

Rekombynantnye vyrusy ymmunnodefytsyta cheloveka / A.F. Bobkov, T.V. Kazennova, L.M. Selymova // Zhurn. mykrobyol. – 1999. – № 1. – S. 45-47.

Vrookes A.J. The essence of SNPs / A.J Vrookes // Gene. – 1999. – Vol. 46, N 2. – P. 236-244.

Enthusiasm mixed with skepticism about single nucleotide polymorphism markers for dissecting complex disorders / A.C. Syvanen, U. Landegren, F. Issakson [et al.] // Eur. J. Hum, Genet. – 1999. – Vol. 7, N 1. – P. 98-101.

CTL escape and increased viremia irrespective of HIV-specific CD4+ T-helper responses in two HIV-infected individuals / [M.J. Geels, C.A. Jansen, E. Baan et al.] // Virology. – 2006. – Vol. 345, N 1. – P. 209-219.

Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure / W.A. Paxton, S.R. Martin, D. Tse [ et al.] // Nat. Med. – 1996. – Vol. 2, N 4. – P. 412-417.

Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32 / [M. Benkirane, D.Y. Jin, R.F. Chun et al.] // J. Biol. Chem. – 1997. – Vol. 272, N 49. – P. 30603-30606.

Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CRR5 structural gene / [M. Dean, M. Carrington, C. Winkler et al.] // Science. – 1996. – Vol. 273, N 5283. – P. 1856-1862.

Petersen D.C. Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population / D.C. Petersen, R.H. Glashoff, S. Shrestha // J. Acquir. Immune Defic. Syndr. – 2005. – Vol. 40, N 5. – P. 521-526.

Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1 / [H. Liu, Y. Hwangbo, S Holte et al.] // J. Infect. Dis. – 2004. – Vol. 190, N 6. – P. 1055-1058.

Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression / [H. Liu, D Chao, E.E. Nakayama et al.] // Proc. Natl. Acad. Sci. USA. – 1999. – Vol. 96, N 8. – P. 4581-4585.

Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men / [I.P. Keet, J. Tang, M.R. Klein et al.] // J. Infect. Dis. – 1999. – Vol. 180, N 2. – P. 299-309.

Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term in human immunodeficiency virus-1-infected individuals / [M. Magierowska, I. Theodorou, P. Debre et al.] // Blood. – 1999. – Vol. 93, N 3. – P. 936-941.

Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10 / [H.D. Shin, C Winkler, J.C. Stephens et al.] // Proc. Natl. Acad. Sci. USA. – 2000. – Vol. 97, N 26. – P. 14467-14472.

Presence of the variant mannosebinding lectin alleles associated with slower progression to AIDS / [J. Maas, M. Brouwer, A. Krol et al.] // AIDS. – 1998. – Vol. 12, N 17. – P. 2275-2280.

Borinskaya S.A. Risk of HIV Infection and Lethality Are Decreased in CCR5del32 Heterozygotes: Focus Nosocomial Infection Study and Meta-analysis / S.A. Borinskaya, Zh. M. Kozhekbaeva, A. V. Zalesov // Acta Naturae. – 2012. – T. 4. – № 1. – S. 42-52.

Hendel H. Distinctive effects of CCR5, CCR2, and SDF1 genetic polymorphisms in AIDS progression // H. Hendel, A. Lebuanec, N. Lachgar Henon // J. Acquir Immune Defic. Syndr. Hum. Retrovirol. – 1998. – Vol. 19. – P. 381-386.

Petersen D.C. Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population / D.C. Petersen, R.H. Glashoff, S. Shrestha // J. Acquir. Immune Defic. Syndr. – 2005. – Vol. 40, N 5. – P. 521-526.

Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1 / [H Liu, Y. Hwangbo, S. Holte et al.] // J. Infect. Dis. – 2004. – Vol. 190, N 6. – P. 1055-1058.

Piddubna A.I. Polimorfizm henu TNF-α (-308g/a) u VIL-infikovanykh osib / A.I. Piddubna // Mater. Vseukr. nauk.-metod. konf. i plenumu Asotsiatsii infektsionistiv Sumshchyny, 19-20 chervnia 2013 r.  Sumy.: Sum DU, 2013. – S. 81-83.

Piddubna A.I. Polimorfizm heniv tsytokiniv u khvorykh na VIL- infektsiiu / A.I. Piddubna, M.D. Chemych // J. Clin. Exp. Med. Res. – 2014. – N 2 (Suppl.1). – R. 29-37.

Analyz polymorfnykh varyantov henov tsytokynov u patsyentov s VYCh-ynfektsyei / [N.A. Sukhalentseva, Y.O Naslednykova, A.S. Chernov y dr.] // Med. ymmunolohyia. – 2011. – T. 13, № 1. – S. 79-82.

Sokolova Yu.V. Osobennosty sekretsyy tsytokynov y ykh retseptsyy v dynamyke VYCh-ynfektsyy / Yu.V. Sokolova, L.P. Syziakyna // Ymmunolohyia. – 2007. – № 6. – S. 324-327.

Shrestha S. Behavioral Risk Exposure and Host Genetics of Susceptibility to HIV-1 Infection / S. Shrestha, A. Strathdees, N. Galai // J. Infect. Dis. – 2006. – Vol. 193. – R. 16-26.

Mogensen T.H. Molecular Pathways in Virus-Indused Cytokine Production / T.H. Mogensen, S.R. Paludan // Microbiol. and Biol. Rev. – 2001. – Vol. 65, N 1. – R. 131-150.

Konenkov V.Y. Polymorfyzm promotornykh rehyonov henov IL-4 y -10 y faktora nekroza opukholei α u VYCh-ynfytsyrovannykh / V.Y. Konenkov, M.V. Smolnykova // Biull. eksperym. byolohyy y medytsyny. – 2002. – № 4. – S. 449-451.

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection / [C. Goujon, O. Moncorgé, H. Bauby et al.] // Nature. – 2013. – N 502. – R. 559-562.