THE ROLE OF THE INTERLEUKIN-6 GENE POLYMORPHISM IN THE COURSE OF CHRONIC HEPATITIS C AND THE FORMATION OF MIXED CRYOGLOBULINEMIA
DOI:
https://doi.org/10.11603/1681-2727.2018.2.9032Keywords:
chronic hepatitis C, mixed cryoglobulinemia, polymorphism of the interleukin-6 gene.Abstract
The aim of the work: to determine the role of the interleukin-6 gene polymorphism in the course of chronic hepatitis C and the development of mixed cryoglobulinemia.
Patients and methods. The study included 149 HCV patients aged from 24 to 73 years old (male – 65.8 %, female – 34.2 %). All patients were evaluated for the content of mixed cryoglobulins in blood serum by spectrophotometric method and polymorphism of IL-6 gene (rs1800795) by polymerase chain reaction. For the analysis of the data, HCV patients were divided depending on the polymorphism of the IL-6 gene and the presence of mixed cryoglobulinemia.
Results and discussion. A certain role of the IL-6 gene polymorphism in chronic HCV infection has been established, which confirms the detection of the CC genotype 3 times less (χ2=21.88, р<0.001) and 1,7 times more than the detection of CG/GG genotypes (χ2=21.88, р<0.001) in patients with HCV, compared with healthy persons. It has been shown that in HCV patients the CG/GG genotypes of IL-6 gene are associated with the emergence of biochemical features of mixed cryoglobulinemia in 67.7 % of patients compared to 36.0 % of patients with the presence of the genotype CC (χ2=8.93, р<0.01). In the presence of biochemical features of mixed cryoglobulinemia in HCV genotypes, the CG/GG genotype IL-6, in comparison with the genotype CC, is associated with higher (p=0.03) content of mixed cryoglobulins in serum and a more frequent manifestation of clinical signs of this extrahepatic manifestation, and the most pronounced general weakness (71.4 % vs. 22.2 %, χ2=8.86, р=0.003), arthralgia (63.1 % vs. 22.2%, χ2=5.62, р=0.02), the appearance of cryoglobulinemic vasculitis with the formation of the Triad of Meltzer (15.5 %).References
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