CHARACTERISTICS OF HIV-ASSOCIATED DISEASES OF THE CENTRAL NERVOUS SYSTEM IN OLDER PEOPLE
DOI:
https://doi.org/10.11603/1681-2727.2018.1.8668Keywords:
HIV-infection, HIV-associated diseases of the central nervous system, age, cognitive impairment.Abstract
The aim of the work is to study the main characteristics of HIV-associated diseases of the central nervous system in persons over 50 years old and to determine the frequency and relationship of chances of development of neurological diseases depending on age aspects.
Patients and methods. A retrospective analysis of 428 medical cards of patients with HIV-associated CNS diseases who were treated at the departments of Dnipropetrovsk regional and municipal AIDS centers in the period from 2010 to 2016 was conducted.
Conclusions. The obtained data testify to the features of HIV-associated diseases of the CNS in patients over the age of 50 years. In this age group, the number of people infected with sexualroute of transmission was significantly higher than among younger people, the HIV infection was diagnosed later and, accordingly, fewer patients received ART. At the time of the development of neurological diseases in patients over 50, a higher level of RNA HIV viral load was observed in the absence of statistically significant immunological differences. In this group, high chances of developing PML, EBV-encephalitis, cognitive impairment, and a tendency towards higher incidence of stroke are identified, which can lead to severe consequences, and underlines the importance of a more detailed consideration of the age aspect.References
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