PREVALENCE OF LYME BORRELIOSIS AMONG TB PATIENTS
DOI:
https://doi.org/10.11603/1681-2727.2017.4.8315Keywords:
tuberculosis, Lyme borreliosis, Borrelia burgdorferi, diagnosis, questionnaire, ECG.Abstract
The aim of the study was to identify the prevalence of Lyme borreliosis among patients with tuberculosis.
Patients and Methods. Under supervision there were 99 patients with tuberculosis (TB) treated at the Ternopil Regional TB Dispensary during 2015–2017. The patients responded to the question of a unified international questionnaire regarding the the history of tick bites and Lyme borreliosis and were examined by ELISA for the presence of antibodies to B. burgdorferi sensu lato.
Results. Antibodies of at least one IgM and / or IgG class to B. burgdorferi sensu lato (B. burgdorferi sensu stricto, B. afzelii and B. garinii) were detected in 25.2 % of the examined patients with TB. Surveyed patients who indicated tick-borne bites, sero-confirmation of borreliosis was obtained in 9 out of 53 (17.0%), among 46 patients with tuberculosis who did not mind mite bites – 16 (34.7 %) (p<0.05). Patients with tuberculosis with concomitant LB significantly more often noted delayed healing of cavities of dacay in (36.0±9.6) % of cases in 2 months of treatment compared with (14.9±4.1) % of patients without it and cardiogram disorders (sinus bradycardia, conduction retardation and repolarization abnormalities) (p<0.05).
Conclusions. The prevalence of Lyme borreliosis in patients with tuberculosis is 25.2 %. Concomitant Lyme borreliosis negatively affects the course of tuberculosis, which manifests itself in the slowed healing of cavities of decay and ECG disorders in this category of patients (p<0.05).References
Davis, N.A., Islamova, Zh.I., Parpieva, N.N., Belocerkovec, V.G., Osipova, S.O. (2012). Vlijanie soputstvujushhih kishechnyh parazitozov na nekotorye pokazateli immunnogo statusa u bol'nyh tuberkuljozom ljogkih [The effect of concomitant intestinal parasites on some indicators of immune status in patients with lung tuberculosis]. Tuberkulez i bolezni legkih, 89(2), 47-50. [in Russian].
Petrenko, V.I. (2010). Suchasnyi pohliad na problemu poiednanoi potriinoi infektsii: tuberkulozu, VIL/SNIDu, hepatytiv B i C [A modern view of the problem of combined triple infections: tuberculosis, HIV/AIDS, hepatitis B and C]. Tuberkuloz, lehenevi khvoroby, VIL-infektsiia, 4 (11), 5-12. [in Ukrainian].
Vasylieva N.А., Ivakhiv О.L., Каchоr V.О., Аvsiukеvych О.Ye, Voloshyn S.B., Prodan А.М., …& Semеnyshyn О.B. (2011). Khvoroba Laima na Ternopilshchyni [Lime-disease in Ternopil region]. Infektsiini khvoroby, 2, 50-53. [in Ukrainian].
Shkilna M.I. (2016). Laim-borelioz u pratsivnykiv lisovykh hospodarstv Ternopilskoi oblasti [Lyme-borreliosis in forestry workers of Ternopil region]. Infektsiini khvoroby, 1(83), 36-40. [in Ukrainian].
Andreichyn, M.A. (Ed.). (2007). Infektsiini khvoroby u zahalnii praktytsi ta simeinii medytsyni [Infectious diseases in general practice and family medicine]. Ternopil: TDMU, Ukrmedknyha, 500 s. [in Ukrainian].
Zadorozhna, V.I., Rudenko, A.O., Klius, V.Iu. (2017). Laim-borelioz – osoblyvo nebezpechna infektsiia. zahrozy ta ryzyky [Lyme borreliosis is a particularly dangerous infection. Threats and risks]. Zbirnyk naukovykh prats «Veterynarna medytsyna», 103, 30-32. [in Ukrainian].
Zinchuk, O.M. (2013). Cyntropichne urazhennia sertsia u khvorykh na Laim-borelioz (kliniko-elektrokardiografichni oznaky, opys klinichnoho vypadku) [Syntropic heart disorders in patients with Lyme borreliosis (clinical and electrocardiographic characteristics presentation of case report)] Lvivskyi klinichnyi visnyk, 2(2), 49-51. [in Ukrainian].
Carranza-Tamayo, C.O., Gomes da Costa, J.N., Bastos, W.M. (2012). Lyme disease in the state of Tocantins, Brazil: report of the first cases. Brazil. J. Infect. Dis., 6(16), 586-589.
Buczek, A., Rudek, A., Bartosik, K., Szymanska, J., Wojcik-Fatla, A. (2009). Seroepidemiological study of Lyme borreliosis among forestry workers in southern Poland. Ann. Agric. Envіron Med., (16), 257-261.
Karpova, E.A., Doroshhenko, A.A., Abolkina, A.E. (2015). Issledovanie krovi i moloka KRS uchebnoj fermy “IrGSHA” na nalichie zabolevanij, peredajushhihsja cherez ukusy kleshhej [The study of blood and milk cattle training farm “IrGSKHA” for disease, is transmitted through tick bites]. Klimat, ekologija, selskoe hozjajstvo Evrazii: Materialy IV mezhdunarodnoj nauchno-prakticheskoj konferencii posvjashhennoj 70-letiju Pobedy v Velikoj Otechestvennoj vojne (1941-1945 gg.) i 100-letiju so dnja rozhdenija A.A. Ezhevskogo (27-29 maja 2015 goda). Chast' I, Irkutsk, 241-246. [in Russian].
Kornaha, S.I. (2012). Stan hemodynamiky i funktsii miokardu u khvorykh na tuberkuloz lehen v protsesi antymikobakterialnoi terapii: klinichne znachennia ta metody korektsii: avtoref. dys. d-r. med. nauk: 14.01.26 [State of hemodynamics and myocardial function in pulmonary tuberculosis patients during antimicobacterial therapy: clinical significance and methods of correction]; DU «Natsionalnyi instytut ftyziatrii i pulmonolohii im. F. H. Yanovskoho Natsionalnoi Akademii medychnykh nauk Ukrainy». K., 30.
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