ACUTE SEPSIS AND ITS CLINICAL VARIATIONS

Authors

  • V. S. Kopcha I. Horbachevsky Ternopil National Medical University https://orcid.org/0000-0001-9499-3733
  • S. I. Shkrobot I. Horbachevsky Ternopil National Medical University https://orcid.org/0000-0002-5115-0207
  • V. I. Korodiuk Municipal Institution of the Ternopil Regional Council «Ternopil Regional Clinical Psychoneurological Hospital»
  • A. M. Musiyenko Municipal Institution of the Ternopil Regional Council «Ternopil Regional Clinical Psychoneurological Hospital»

DOI:

https://doi.org/10.11603/1681-2727.2022.4.13704

Keywords:

sepsis, septicemia, septicopyemia, septic (infectious) endocarditis, clinical manifestations, diagnosis, clinical case

Abstract

The problem of acute sepsis as a polyetiological acyclic disease with peculiar clinical symptoms and diagnostic difficulties, which requires special treatment, is considered. The predictors of acute sepsis and the variety of clinical manifestations of its two classical stages – septicemia and septicopyemia – are characterized in detail.

A typical case of acute sepsis, which was diagnosed only later, is given. In this regard, etiotropic therapy was delayed. Therefore, despite powerful etiotropic therapy, the disease was not limited to acute sepsis, but continued in the form of infectious (septic) endocarditis.

The septic nature of infectious endocarditis is due to the presence and persistence of a septic focus in the endocardium, as well as the course of the disease in the form of continuous growth of local inflammatory and destructive changes in primary septic foci and general infectious-metastatic, thromboembolic and immune complex manifestations, which in the absence of special treatment lead to an inevitable fatal outcome, that is, the development of a disease such as sepsis acyclicity.

The diagnosis of infective endocarditis is based on the detection of initially reasonably suspicious clinical and then evident paraclinical signs of the disease. Classical clinical and morphological signs of infectious endocarditis, as well as general principles of therapy of such patients, are given.

Author Biographies

V. S. Kopcha, I. Horbachevsky Ternopil National Medical University

MD, Professor of the Infectious Diseases and Epidemiology, Skin and Venereal Diseases Department, I. Horbachevsky Ternopil National Medical University

S. I. Shkrobot, I. Horbachevsky Ternopil National Medical University

MD, Professor, Head of the Neurology Department, I. Horbachevsky Ternopil National Medical University, Ukraine

V. I. Korodiuk, Municipal Institution of the Ternopil Regional Council «Ternopil Regional Clinical Psychoneurological Hospital»

medical director of Municipal non-profit enterprise “Ternopil Regional Clinical Psychoneurological Hospital” of Ternopil Regional Council, Ternopil, Ukraine

A. M. Musiyenko, Municipal Institution of the Ternopil Regional Council «Ternopil Regional Clinical Psychoneurological Hospital»

PhD, Head of ICU of Municipal non-profit enterprise “Ternopil Regional Clinical Psychoneurological Hospital” of Ternopil Regional Council, Ternopil, Ukraine

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Published

2023-04-14

How to Cite

Kopcha, V. S., Shkrobot, S. I., Korodiuk, V. I., & Musiyenko, A. M. (2023). ACUTE SEPSIS AND ITS CLINICAL VARIATIONS. Infectious Diseases – Infektsiyni Khvoroby, (4), 55–71. https://doi.org/10.11603/1681-2727.2022.4.13704

Issue

Section

Reviews and lectures