NEUROIMMUNOLOGICAL CHANGES IN EARLY DIAGNOSTICS OF HIV INFECTION
DOI:
https://doi.org/10.11603/1681-2727.2021.3.12497Keywords:
diagnosis, neuroAIDS, neurospecific proteinsAbstract
The aim of the study – analysis of the influence of neurospecific proteins on the development of neuroAIDS, their role in the pathogenesis, determining the prospects of involvement in the early diagnosis of HIV infection.
The study used theoretical methods that included analysis and synthesis of the study of modern world research, clinical observations, deductive-inductive methods.
Conclusions. There is an active spread and late detection of HIV infection in Ukraine. Standard methods of laboratory diagnosis are unable to provide quality early diagnosis of HIV infection.
The rapid penetration of the virus into the CNS creates difficulties for differential diagnosis with the subsequent formation of resistance to ART. As long as HIV in the blood remains in a long latent period, the pathogen is actively functioning in brain cells.
The connections and features of accumulation of matrix HIV-protein p-17 in the CNS, activity of transcriptional transactivator, regulatory protein Vpr remain poorly studied. Neurospecific proteins as markers of viral pathological process in the human nervous system need special attention and study.
Review of the basics of early diagnosis of HIV will provide opportunities to strengthen epidemiological control and prevent new cases of the disease, which will ultimately lead to a reduction in government funding of this problem not only in Ukraine but also in many countries.
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