Severe pseudomembranous colitis – peculiarities, diagnosis and treatment: case report

Authors

  • Yu. S. Lysiuk Danylo Halytskyi Lviv National Medical University
  • L. M. Kohut Danylo Halytskyi Lviv National Medical University
  • D. L. Romanchak Danylo Halytskyi Lviv National Medical University

DOI:

https://doi.org/10.11603/2414-4533.2017.2.7945

Keywords:

antibiotic-associated diarrhea, ceftriaxone, pseudomembranous colitis, treatment, vancomycin.

Abstract

The aim of the work: based on the clinical case study to focus on the difficulties of diagnosis and treatment of severe pseudomembranous colitis.

Materials and Methods. Prospectively there were studied the peculiarities of severe pseudomembranous colitis in a patient who was treated at the City Community Ambulance Hospital of Lviv. The diagnosis was based on clinical data, results of ultrasonography (USG) fibrosigmoscopy (FSS), computed tomography (CT).

Results and Discussion. The article presents a case of pseudomembranous colitis of a 42-year-old patient after preoperative chemotherapy and a short-term treatment by antibacterial drug (ceftriaxone) used in the postoperative period. The clinical symptoms of severe colitis, the results of diagnosis using ultrasound, flexible sigmoidoscopy, and computer tomography are described. The difficulties of treatment, necessity of correction of medical pattern according to the clinical course, the efficiency of vancomycin long-term prescription are analyzed.

References

Kazanowski, M., Smolarek, S., Kinnarney, F., & Grzebieniak, Z. (2014). Clostridium difficile: epidemiology, diagnostic and therapeutic possibilities – a systematic review. Tech. Coloproctol., 18 (3), 223–232.

Zinchuk, O. M., Zubach, O. O., & Stoliar, H. L. (2014). Suchasni aspekty Clostridium difficile-infektsii [Modern aspects of Clostridium difficile-infection]. Infektsiini khvoroby – Infection Diseases, 3, 5–12 [in Ukrainian].

Surawicz, C. M., Brandt, L. J., Binion, D. G., Ananthakrishnan, A. N., Curry, S. R., Gilligan, P. H., & McFarland, L. V. (2013). Guidelines for Diagnosis, Treatment, and Prevention of Clostridium difficile Infections. Am. J. Gastroenterol., 108, 478–498.

Al-Jashaami, L.S., & DuPont, H.L. (2016). Management of clostridium difficile infection. Gastroenterology & Hepatology, 12 (10), 609-616.

Deshpande, A., Pasupuleti, V., Thota, P., Pant, C., Rolston, D. K., Hernandez, A. V., & Donskey, C. J. (2015). Risk factors for recurrent clostridium difficile infection: a systematic review and meta-analysis. Infection Control & Hospital Epidemiology, 36 (04), 452–460.

Bonasera, J., Kramer, J. K., & Ho, S. (2004). Relapsing clostridium difficile colitis robert. Practical Gastroenterology, May, 78–80.

Cornely, O. A., Miller, M. A., Fantin, B., Mullane, K., Kean, Y., & Gorbach, S. (2013). Resolution of clostridium difficile–associated diarrhea in patients with cancer treated with fidaxomicin or vancomycin. Journal of Clinical Oncology, 31 (19), 2493–2499.

Hawrelak, J. A., & Myers, S. P. (2004). The causes of intestinal dysbiosis: a review. Alternative Medicine Review, 9 (2), 180–197.

Sartelli, M., Malangoni, M. A., Abu-Zidan, F. M., Griffiths, E. A., Bella, S. D., McFarland, L. V., & Eltringham, I. (2015). WSES guidelines for management of Clostridium difficile infection in surgical patients. World Journal of Emergency Surgery, 10 (38), 1–23.

Crobach, M. J. T., Planche, T., Eckert, C., Barbut, F., Terveer, E. M., Dekkers, O. M., & Wilcox, M. H. (2016). European Society of Clinical Microbiology and Infectious Diseases: update of the diagnostic guidance document for Clostridium difficile infection. Clinical Microbiology and Infection, 22, 63–81.

Аlekseyechkina, O. A., Dubrov, E. Ya., Vladimirova, Ye. S., Pinchuk, T. P., & Titova, G. P. (2012). Vozmozhnosti ultrazvukovogo issledovaniya v diagnostike psevdomembranoznogo kolita u khirurgicheskikh bolnykh [Potential of ultrasound investigation in diagnostics of pseudomembranous colitis in surgical patients]. RZhGGK – Russian Journal of Gastroenterology, Hepatology and Coloproctology, 2, 29–35 [in Russian].

Debast, S. B., Bauer, M. P., & Kuijper, E. J. (2014). European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Clinical Microbiology and Infection, 20 (2), 1–26.

Published

2017-07-14

How to Cite

Lysiuk, Y. S., Kohut, L. M., & Romanchak, D. L. (2017). Severe pseudomembranous colitis – peculiarities, diagnosis and treatment: case report. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (2), 85–90. https://doi.org/10.11603/2414-4533.2017.2.7945

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