Breast sarcomas: methods of adjuvant treatment
DOI:
https://doi.org/10.11603/2414-4533.2017.2.7536Keywords:
breast sarcomas, chemotherapy, radiation treatment, surgery.Abstract
The aim of the work: to conduct retrospective analysis of adjuvant treatment methods for patients with breast sarcoma, which are located in the database of cancer registry of 15 regional oncol ogy dispensaries of Ukraine.
Materials and Methods. 378 cases of breast sarcoma were registered for the period of 2000–2015 under the ciphers 3227, 3332, 3235 and 3254 in regional oncological dispensaries. Attention was paid to the treatment of 360 women with breast sa rcoma.
Treatment: the surgical method was used for 81 patients (22.5 %); for 179 patients (49.7 %) a complex treatment was used: surgical + chemotherapy and/or radiation therapy, 74 patients (20.6 %) received only chemotherapy, radiotherapy or a combination of these methods; 26 patients (7.2 %) did not receive treatment because of refusal or contraindications.
For systemic chemotherapy the CAF, CMF and AC schemes were used. Radiotherapy applied in neoadjuvant (36-40 Gy) and postoperative (40-65 Gy) regimens.
Results and Discussion. Surgical methods play a major role in treating of breast sarcomas; the overall one-year survival rate is 80.2 %, three years – 51.9 % and five years – 43.2 %. The combination of surgical methods with adjuvant chemotherapy and radiation therapy did not have the benefits of survival in patients, compared with one surgical method. The overall one-year survival rate for patients was 80.4%, three years – 56.4 %, five years – 31.3 %.
Adjuvant methods of chemotherapy and radiation therapy in an independent mode do not reach the results of surgical treatment. The overall one-year survival rate of patients was 63.5 %, three-years – 32.4 %, and five-years – 13.5 %, which is significantly lower (p <0.05), than in surgical treatment groups.
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