Features Of The Paretic Limb Spasticity And Function Level Correlation After Different Types Of Neurotransplantation On The Model Of Spinal Cord Injury

Authors

  • V. V. Medvediev The National Academy of Medical Sciences of Ukraine, State Institution Institute of Neurosurgery. Acad. AP Romodanov NAMS Ukraine

DOI:

https://doi.org/10.11603/2414-4533.2017.1.7247

Keywords:

spinal cord injury, post-traumatic spasticity syndrome, spinal cord function recovery, tissue neurotransplantation, correlation.

Abstract

The aim of the work – to explore the correlation of spasticity and function level in the paretic limb after different types of neurotransplantation on the model of spinal cord injury.

Materials and Methods. Animals – white inbred rats (males, 5.5 months, ~ 350 g); groups: “control” – the left-side spinal cord hemisection at T11 (n=16), “TOBT” – analogous spinal cord injury + immediate allogenic homotopical transplantation of the olfactory bulb tissue (n=34), “TFCT” – analogous spinal cord injury + immediate allogenic homotopical transplantation of a fetal (E18) cerebellum tissue (n=15); “TFKT” – analogous spinal cord injury + immediate allogenic homotopical transplantation of a fetal (E18) kidney tissue (n=8). Monitoring of the ipsilateral hind limb (IHL) function and spasticity indicator (FI and SI respectively) – Basso-Beattie-Bresnahan (BBB) scale and Ashworth scale, respectively.

Results and Discussion. TOBT provides reliable advantage of IHL FI with a maximum in 3rd week (3.7 ± 0.5 points BBB), followed by a gradual decrease to 2.4±0.6 points BBB (24th week), reduces the severity of spasticity in the early period of trauma. TFCT transforms dynamics of the IHL FI from a progressive to constant with fluctuations within interval 3–3.6 points BBB, significantly improves spasticity during 1st–3rd week, further stabilizes the IHL SI at 1.8–2.1 points Ashworth. TFKT causes a progressive (1st month) and progressive-to-constant (6th–24th week) phase of IHL FI dynamics, significantly improves spasticity during the first two weeks. Correlation between the average (for the group) value of mean value of IHL FI and SI during observation period was absent in group “TFCT”, in group “control” was found weak positive correlation, in group “TFKT” – moderate positive correlation, in group “TOBT” – strong negative correlation. Correlation analysis of individual IHL FI and SI values during observation period and at each time of observation indicates the predominance of negative correlation between them.

Conclusions. Variability of the correlation between IHL FI and SI indicates significant differences in breadth of supraspinal projection coating of IHL motoneurons populations, their survival during experiment after different types of tissue neurotransplantation.

Author Biography

V. V. Medvediev, The National Academy of Medical Sciences of Ukraine, State Institution Institute of Neurosurgery. Acad. AP Romodanov NAMS Ukraine

к.мед.н., доцент, доцент кафедри нейрохірургії Національного медичного університету імені О.О. Богомольця

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Published

2017-06-19

How to Cite

Medvediev, V. V. (2017). Features Of The Paretic Limb Spasticity And Function Level Correlation After Different Types Of Neurotransplantation On The Model Of Spinal Cord Injury. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (1), 51–57. https://doi.org/10.11603/2414-4533.2017.1.7247

Issue

No. 1 (2017)

Section

EXPERIMENTAL INVESTIGATIONS

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