Efficiency of microgranular form of 5-aminosalicylic acid in the postoperative period of complicated Crohn's disease
DOI:
https://doi.org/10.11603/2414-4533.2016.4.7193Abstract
The modern concept of surgical treatment of Crohn's disease head towards the implementation of economical resection of bowel, the use of minimal-invasive techniques. At the same time, the operation can not always prevent the recurrence and progression of disease and there is a need of further medical therapy in the postoperative period. Among 35 patients in 14 of them underwent laparoscopic sanitation and drainage of the abdominal cavity, 5 – sectoral resection of modified fragment of the small intestine with the formation of entero-entero-anastomosis, 13 – resection of the ascending colon and a meter of the small intestine with the formation of entero-enteroanastomosis, 3 – laparoscopic resection of the descending part of the colon. In the postoperative period all of these patients were divided into 2 groups, one of which (18 patients) on the background of detoxification and antibiotic therapy took microgranular form of 5-aminosalicylic acid (Pentasa 2000 mg orally and 1000 mg in suppositories) and the other (17 patients) only detoxification and antibiotic therapy. There were found that in patients with Crohn's disease treated with Pentase pain disappeared in 18.36 % more of cases, body temperature normalized in 2–3 days earlier, normalization of stool begun in 2 days earlier comparing to another group. Under the influence of Pentase in operated patients level of C-reactive protein and histamine concentration significantly reduced, and monocytic endothelial protein (EMAP-II) – increased as an antiinflammatory factor in comparison to patients, who did not receive pathogenetic therapy in the postoperative period.
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