The variability of the paretic limb function and spasticity correlation for various restorative process flow on the spinal cord injury model
DOI:
https://doi.org/10.11603/2414-4533.2016.4.7180Abstract
The goal of the work – to explore the correlation of spasticity and function level of paretic limbs on the spinal cord injury model. Animals – white inbred males, rats (5.5 months, ~ 350 g); groups: “control” – the left-side spinal cord hemisection at T11 (n=16), “foreign body” – immediate implantation of fragment of the microporous hydrogel in the locus of spinal cord injury (n=10); “neurogel” – implantation of the NeuroGelTM fragment under similar conditions (n=20). Monitoring of the ipsilateral hind limb (IHL) function and spasticity indicator (FI and SI respectively) – Basso-Beattie-Bresnahan (BBB) scale and Ashworth scale, respectively. Implantation of NeuroGelTM significantly improves the efficiency of the functional recovery by 7 points of BBB scale, reduces spasticity by 1 point of Ashworth scale. Foreign body persistence worsens the course of the traumatic process during the 2nd–4th-month, significantly reduce IHL FI and increase SI. IHL FI and SI in groups “control” and “neurogel”, unlike the group “foreign body”, do not show a strong negative correlation (r > –0.75). In the group “neurogel” we found a positive correlation between IHL FI and SI during the observation period. Spinal cord regeneration significantly modifies IHL FI and SI correlation, probably by increasing the number of motoneurons effectively controlled by supraspinal influences.
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