MODERN APPROACHES TO THE DIAGNOSIS AND TREATMENT OF UNFORMED AND FORMED CYSTS OF THE PANCREAS

Authors

DOI:

https://doi.org/10.11603/2414-4533.2024.3.14920

Keywords:

pancreatic cyst, surgical management, endoscopic cystgastrostomy

Abstract

The aim of the work: to improve the results of surgical treatment of pancreatic cysts by retrospective analysis of the clinical course, assessment of morphological classification and optimal choice of surgical treatment of cysts.

Materials and Methods. The study was conducted on the basis of the Сlinical Highly Specialized Surgical Center with Minimally Invasive Technologies of the Vinnytsya Regional Hospital. To achieve the purpose, an in-depth analysis of the results of treatment of 60 patients who underwent operations for pancreatic cysts between 2018 and 2023 was conducted.

Results and Discussion. The study included 60 patients who underwent surgery for pancreatic cysts: in 2018 – 6 patients, in 2019 – 7, in 2020 – 10, in 2021 – 11, in 2022 – 9 and in 2023 – 17 patients, which indicates the preservation of the tendency towards the growth of this pathology. By gender, men prevail – 43 (71.7 %) patients; women – 17 (28.3 %). The average age of patients is 48.1±1.1 years, which gives this problem a socio-economic significance. According to the data of radiological research methods, the most frequent localization is a combination of cysts in the head and body of the pancreas – in 20 (33.3 %) patients. According to the course, cysts were simple in 18 (30 %) patients, and in 42 (70 %) – complicated. All patients underwent surgical interventions, the share of which, according to our data, is 0.34 % of the total number of operations at the Center during the study period. Due to suppuration of cysts, 27 (45 %) patients underwent external drainage of pancreatic cysts. For 32 (53.3 %) patients, the method of surgical treatment was chosen to apply a cyst-enteroanastomosis on the excluded loop of the intestine according to Roux or an application of a cyst-enteroanastomosis with an entero-enteroanastomosis and a plug according to Shalimov. Another 1 (1.7 %) patient underwent endoscopic cyst-gastrostomy. There were no fatal consequences.

References

European Study Group on Cystic Tumours of the Pancreas. European evidence-based guidelines on pancreatic cystic neoplasms. Gut 2018; 67(5): 789–804. DOI: 10.1136/gutjnl-2018-316027

Jones M, Zheng Z, Wang J, Dudley J, Albanese E, Kadayifci A, … & Pitman MB. Impact of next-generation sequencing on the clinical diagnosis of pancreatic cysts. Gastrointestinal endoscopy. 2016; 83(1): 140–148. DOI:10.1016/j.gie.2015.06.047

Jones MJ, Buchanan AS, Neal CP, Dennison AR, Metcalfe MS, & Garcea G. Imaging of indeterminate pancreatic cystic lesions: a systematic review. Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013; 13(4): 436–442. DOI: 10.1016/j.pan.2013.05.007

Lee LS. Updates in diagnosis and management of pancreatic cysts. World journal of gastroenterology. 2021; 27(34): 5700–5714. DOI: 10.3748/wjg.v27.i34.5700

Singhi AD, Zeh HJ, Brand RE, Nikiforova MN, Chennat JS, Fasanella KE, … & McGrath K. American Gastroenterolo­gical Association guidelines are inaccurate in detecting pancreatic cysts with advanced neoplasia: a clinicopathologic study of 225 patients with supporting molecular data. Gastrointestinal endo­scopy. 2016; 83(6): 1107–1117.e2. DOI: 10.1016/j.gie.2015.12.009

Springer S, Wang Y, Dal Molin M, Masica DL, Jiao Y, Kinde I, … & Lennon AM. A combination of molecular markers and clinical features improve the classification of pancreatic cysts. Gastroentero­logy. 2015; 149(6): 1501–1510. DOI: 10.1053/j.gastro.2015.07.041.

Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, … & Wolfgang CL. Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas. Pancreatology: official journal of the International Association of Pancreatology (IAP). 2017; 17(5): 738–753. DOI: 10.1016/j.pan.2017.07.007

Vege SS, Ziring B, Jain R, Moayyedi P. Clinical Guidelines Committee, & American Gastroenterology Association (2015). American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts. Gastroenterology. 2015; 148(4): 819–822. DOI: 10.1053/j.gastro.2015.01.015

Kanikovskyi OE, Pavlyk IV, Oliynyk IV, & Makhovskyi OL. Alhorytm likuvannia psevdokist pidshlunkovoi zalozy u khvorykh na khronichnyi pankreatyt [Algorithm for the treatment of pseudocysts of the pancreas in patients with chronic pancreatitis]. Naukovyy visnyk Uzhhorodsʹkoho universytetu – Scientific Bulletin of the Uzhhorod University. Uzhhorod: "Lira". 2018; 1(57): 64–69. [in Ukrainian] http://visnyk-med.uzhnu.edu.ua/article/download/183697/183552

Shevelev VV, Ratchik VM, & Orlovsky DV. Kisty pidshlunkovoi zalozy : suchasni uiavlennia pro patohenez, diahnostyku ta likuvalno-diahnostychnu taktyku [Pancreatic cysts: modern ideas about pathogenesis, diagnosis and treatment and diagnostic tactics]. Hastroenterolohiya – Gastroenterology. 2014; 3(53):43-50. [in Ukrainian]

Published

2024-09-02

How to Cite

SHAPRYNSKYI, V. O., KAMINSKYI, O. A., TAGEEV, V. R., MYRONYSHEN, Y. A., MAKAROV, V. M., CHERNYCHENKO, O. I., … VERBA, M. A. (2024). MODERN APPROACHES TO THE DIAGNOSIS AND TREATMENT OF UNFORMED AND FORMED CYSTS OF THE PANCREAS. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (3), 22–27. https://doi.org/10.11603/2414-4533.2024.3.14920

Issue

Section

ORIGINAL INVESTIGATIONS