The effect of automesoconcentrate of platelets on the functional state of the liver of rats after partial resection of the liver parenchyma
DOI:
https://doi.org/10.11603/2414-4533.2023.3.14149Keywords:
liver, resection, platelet automesoconcentrate, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferaseAbstract
The aim of the work: to determine the markers of the functional state of the liver in rats after partial resection of the liver parenchyma under the conditions of using automesoconcentrate of platelets (AMC).
Materials and Methods. Experimental studies were conducted on white Wistar laboratory rats, which were divided into three groups: group I – intact animals (control); group II – animals that underwent resection of the left lobe of the liver without further additional therapy; group III – animals that were injected with AMC after partial resection of the left lobe of the liver.
Results and Discussion. It was established that on in the initial stages after partial liver resection was observed alanine aminotransferase (ALT) hyperenzymemia, aspartate aminotransferase (AST), γ-glutamyltransferase (GHT), which indicates on damage to liver cells and low intensity of processes regeneration. Introduction of AMC already on the 6th day after surgery contributed to the reduction of ALT, AST and GGT in blood serum, with normalization studied indicators on the 18th day of the experiment. The introduction of AMC contributed more significant restoration of the protein-synthesizing function of the liver for what indicate lower values of the thymol test compared to the indicators of the group animals that were not administered AMC.
Administration of AMA triggers faster regenerative processes in the liver, as evidenced by a decrease in aminotransferase hyperenzymemia, HGT and thymol test. The normalization of liver samples indicates the restoration of the structural and functional state of this organ.
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