Experimental study of the influence of a bioresorbable vascular stent platform
DOI:
https://doi.org/10.11603/2414-4533.2022.4.13612Keywords:
bioresorbable vascular stent-platforms, tissue reaction, histological examinationAbstract
The aim of the work: to investigate the effect of bioresorbable vascular stent-platforms «Absorb» (Abbott, USA) on the surrounding tissues in the area of its implantation, as well as the features of resorption of the stent-platform.
Material and Methods. In the study, histological preparations of nine three-month-old white laboratory rats weighing 150-170 g were studied, which were implanted with a fragment of biodegradable vascular stent-platforms in the great omentum and subcutaneously. Animals were removed from the experiment 30, 90, and 180 days after the intervention.
Results and Discussion. During the study of histological preparations in the area of implantation under the skin in the period of 30 and 90 days, and 30 days after implantation in the great omentum, areas of lymphocytic macrophage infiltration and fibrosis of the capsule were found. However, when examining histological preparations of the following periods of the experiment, a significant decrease in the intensity of perifocal inflammatory and vascular reactions with the formation of mostly thin capsules was noted. Also, at 90 and 180 days, structureless material similar to tissue detritus was found on the inner surface of individual capsules, which probably indicates a more pronounced destruction of the stent layers than in the previous periods.
Implantation of stent fragments was not accompanied by a pronounced inflammatory reaction. A gradual increase in focal lymphocytic infiltration in the implantation zone was observed from 30 to 90 days with a significant decrease in the intensity of the latter at 180 days. Macrophage reaction increased in terms of 30 to 180 days, which indicates the benefit of gradual biodestruction of the stent material. Resorption of the stent beams occurred moderately, starting mainly from day 90 with the formation of small granules of foreign bodies with single giant cells of foreign bodies. The use of implants was not accompanied by tissue deformations, seroma formation and other negative consequences. The absence of a pronounced irritating effect indicates biocompatibility with body tissues.
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