Pathogenetic justification of immunocorrection in patients with erysipelas, depending on the form and features of the disease course
DOI:
https://doi.org/10.11603/2414-4533.2022.4.13601Keywords:
erysipelas, cellular link of the system, immunomodulatorsAbstract
The aim of the work: to study of the state of the cellular link of the immune system in patients with various forms and course of erysipelas with further justification of the appointment of immunomodulators.
Materials and Methods. We examined 130 patients with erysipelas of the face, upper and lower extremities. To assess the immune status, subpopulations of lymphocytes were determined using monoclonal antibodies to antigens CD3+ (T-lymphocytes), CD4+ (T-helpers), CD8+ (T-suppressors), CD16+ (killer cells), DM22+ (mature B-lymphocytes), and the immunoregulatory index (IRI) of DM4+/DM8+ was also calculated. Determination was carried out with reagents of the Kharkiv company "Granum". To detect disorders of the immune system, a universal method of assessing immune disorders, developed by рrofessor A.M. Zemskov, was used. (1996).
Results and Discussion. As a result of the research, it was established that all forms of primary and recurrent erysipelas (the bullous form is an exception) occurred against the background of secondary immunodeficiency. The degree of immune disorders varied depending on the severity of the course of the disease. Primary erysipelas with erythematous and bullous forms is characterized by the I degree of immune disorders, while primary erysipelas complicated by sepsis and phlegmonous-necrotic form in the primary and recurrent course is characterized by the II degree, and the recurrent course complicated by sepsis is characterized by the III degree of immune disorders.
Patients with pyelonephritis of all forms occurring against the background of secondary immunodeficiency in the first degree of immune disorders (which is obviously a transient state) do not need correction with immunomodulators, while patients with II and III degrees of immune disorders, being immunologically compromised, require mandatory prescription of immunomodulators (both biological and synthetic origin).
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