Diagnostic criteria of acute destructive pancreatitis

Authors

  • V. M. Likhman V. T. Zaytsev Institute of General and Urgent Surgery, National Academy of Medical Sciences of Ukraine
  • A. O. Merkulov V. T. Zaytsev Institute of General and Urgent Surgery, National Academy of Medical Sciences of Ukraine
  • O. M. Shevchenko Kharkiv National Medical University
  • S. V. Tkach V. T. Zaytsev Institute of General and Urgent Surgery, National Academy of Medical Sciences of Ukraine
  • D. O. Miroshnichenko Kharkiv National Medical University
  • E. O. Beloded Kharkiv National Medical University
  • N. V. Batsman Kharkiv National Medical University
  • K. M. Yatsko V. T. Zaytsev Institute of General and Urgent Surgery, National Academy of Medical Sciences of Ukraine

DOI:

https://doi.org/10.11603/2414-4533.2021.3.12535

Keywords:

acute pancreatitis, pancreatic necrosis, diagnostics

Abstract

The aim of the work: to study the proteins of the acute phase in the blood of patients with acute pancreatitis of varying severity.

Materials and Methods. The study is based on the results of examination of 88 patients with acute pancreatitis of varying severity who were treated at the Institute of the General and Urgent Surgery named after V. T. Zaytsev, Academy of Medical Sciences of Ukraine, Kharkiv, as well as 45 donors (control group).

Results and Discussion. The determination of the activity of serum enzymes in the dynamics of acute destructive pancreatitis was carried out. The parameters were verified before the operation and after the operative treatment in dynamics, as well as before and after the se­cond operation in the dynamics. Markers of tissue destruction can simultaneously serve as indicators of the severity of the inflammatory process in the pancreas and determine the quality of the performed surgical intervention. The diagnostic value of ferritin and lactofferin as markers of an acute destructive process was proved on the basis of a significant increase in their level in blood serum and exudates of patients. It was shown that ferroproteins are reliable markers of the inflammatory process, among others, including classical acute phase proteins. At the same time, their identification is distinguished by its explicitness in the diagnosis of not only latent destructive states.

The detected changes in the concentration of clinical and laboratory parameters of alpha-2-macroglobulin, lactoferrin, C-reactive protein, ferritin in the blood serum correlate with the degree of the inflammatory process and purulent-destructive changes in the pancreas.

References

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Published

2021-12-03

How to Cite

Likhman, V. M., Merkulov, A. O., Shevchenko, O. M., Tkach, S. V., Miroshnichenko, D. O., Beloded, E. O., … Yatsko, K. M. (2021). Diagnostic criteria of acute destructive pancreatitis. Hospital Surgery. Journal Named by L.Ya. Kovalchuk, (3), 23–29. https://doi.org/10.11603/2414-4533.2021.3.12535

Issue

No. 3 (2021)

Section

ORIGINAL INVESTIGATIONS

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