Npwt usage in diabetic foot necrotic-purulent lesion treatment
DOI:
https://doi.org/10.11603/2414-4533.2021.2.12302Keywords:
diabetic foot, NPWTAbstract
The aim of the work: to specify indications and effectiveness of NPWT in treating diabetic patients with necrotic-purulent foot lesion.
Materials and Methods. NPWT was applied to treat a necrotic-purulent diabetic foot lesion of 15 patients. All of them had diabetes type 2 for 8–23 years long, median 12 years. Glycemia control with pills used 6 patients, by insulin injection – 9.
For NPWT Acelity (USA) utensil was used. Aspiration was conducted with 100–120 mm Hg pressure during 8–10 minutes alternating with 60–70 mm Hg pressure during 2–3 minutes.
We have no reason for looking for another mode of NPWT. Maybe such reason will appear with the greater amount of cases with different leg and patient characteristics.
There was a serious adverse event in 6 % of cases of NPWT observed by other physicians. We did not have any serious complication.
Just by the controlled blinded clinical study NPWT was not superior to standard moist wound care in the diabetic foot cases primarily in the rate of wound closure. Nevertheless, our experience to find out patients for whom NPWT was critical in foot saving while moist wound care was ineffective and with a high risk of high amputation. The accumulation of more such observations will help to more accurately determine the place of NPWT in the treatment of diabetic foot.
References
Beckerath , O. von, Zapenko, A., Dissemond, J., & Kröger, K. (2017). Initiative Chronische Wunden (ICW) e.V. Ten-year analyses of the German DRG data about negative pressure wound therapy. Int. Wound J. 14 (3), 501-507. DOI: 10.1111/iwj.12635. Epub 2016 Jul 4.
Huang, Q., Wang, J.-T., Gu, H.-C., Cao, G., & Cao J.-C. (2019). Comparison of vacuum sealing drainage and traditional therapy for treatment of diabetic foot ulcers: a meta-analysis. J. Foot Ankle Surg., 58 (5), 954-958. DOI: 10.1053/j.jfas.2018.12.020.
Rayman, G., Vas, P., Dhatariya, K., Driver, V., Hartemann, A., Londahl, M., Piaggesi, A., Apelqvist, J., Attinger, C., & Game, F. (2020). International Working Group on the Diabetic Foot (IWGDF) Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update) Diabetes Metab. Res. Rev., 36, Suppl, 1, e3283. DOI: 10.1002/dmrr.3283.
Wynn, M., & Freeman, S. (2019). The efficacy of negative pressure wound therapy for diabetic foot ulcers: A systematised review. J. Tissue Viability, 28 (3), 152-160. DOI: 10.1016/j.jtv.2019.04.001. Epub 2019 Apr 10.
Rys, P., Borys, S., Hohendorff, J., Zapala, A., Witek, P., Monica, M., Frankfurter, C., Ludwig-Slomczynska, A., Kiec-Wilk, B., & Malecki M.T. (2020). NPWT in diabetic foot wounds-a systematic review and meta-analysis of observational studies. Endocrine, 68 (1), 44-55. DOI: 10.1007/s12020-019-02164-9. Epub 2020 Jan 9.
Liu, Z., Dumville, J. C., Hinchliffe, R. J., Cullum, N., Game, F., Stubbs, N., Sweeting, M., & Peinemann F. (2018). Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus. Meta-Analysis Cochrane Database Syst. Rev., 17; 10 (10). CD010318. doi:10.1002/14651858.CD010318.pub3.
Jhamb, S., Vangaveti, V.N., & Malabu, U.H. (2016). Genetic and molecular basis of diabetic foot ulcers: Clinical Review J. Tissue Viability, 25 (4), 229-236. DOI: 10.1016/j.jtv.2016.06.005. Epub 2016 Jun 25.
Karam, R.A., Rezk, N.A., Rahman, T.M.A., & Al Saeed, M. (2018). Effect of negative pressure wound therapy on molecular markers in diabetic foot ulcers Gene, 667, 56-61. DOI: 10.1016/j.gene.2018.05.032. Epub 2018 May 11.
Zhang, D., Li, Z., Wang, Z., Zeng, F., Xiao, & Yu, W.A. (2019). MicroRNA-126: a promising biomarker for angiogenesis of diabetic wounds treated with negative pressure wound therapy. Diabetes Metab. Syndr. Obes., 12, 1685-1696. DOI: 10.2147/DMSO.S199705. eCollection 2019.
Borgquist, O., Ingemansson, R., & Malmsjö, M. (2010). Wound edge microvascular blood flow during negative-pressure wound therapy: examining the effects of pressures from -10 to -175 mmHg. Plast. Reconstr. Surg., 125 (2), 502-509. DOI: 10.1097/PRS.0b013e3181c82e1f.
Xing, D., Yang, Z., Cao, C., Dong, Z., Wei, J., Zheng, X., & Li, W. (2020). A modified negative pressure wound therapy for the treatment of refractory wounds. A Preliminary Study Medicine (Baltimore), 99 (28), e21148. Published online 2020 Jul 10. doi: 10.1097/MD.0000000000021148 PMCID: PMC7360312 PMID: 32664147
Liu, S., He, C.-Z., Cai, Y.-T., Xing, Q.-P., Guo, Y.-Z., Chen, Z.-L., Su, J.-L., & Yang, L.-P. (2017). Evaluation of negative-pressure wound therapy for patients with diabetic foot ulcers: systematic review and meta-analysis. Ther. Clin. Risk Manag., 13, 533-544. DOI: 10.2147/TCRM.S131193. eCollection 2017.
Seidel, D., Storck, M., Lawall, H., Wozniak, G., Mauckner, P., Hochlenert, D., Wetzel-Roth, W., Sondern, K., Hahn, M., Rothenaicher, G., Krönert, Th., Zink, K., Neugebauer, E. (2020). Negative pressure wound therapy compared with standard moist wound care on diabetic foot ulcers in real-life clinical practice: results of the German DiaFu-RCT Randomized Controlled Trial. BMJ Open, 10 (3), e026345. DOI: 10.1136/bmjopen-2018-026345.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Hospital Surgery. Journal named by L.Ya. Kovalchuk
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish their work in Hospital Surgery. Journal by L. Ya. Kovalchuk agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).