THE CHOICE OF PROTECTIVE POLYMER COATING FOR THE L-ARGININE WITH THIOTRIAZOLINE CORE TABLETS

Abstract

The aim of the work. The choice a protective polymer film-forming system for coating of L-arginine with thiotriazoline core tablets.

Materials and methods. In the course of work for the production of core tablets, thiotriazolin, L-arginine and registered excipients were used. The core tablets were prepared by the wet granulation method in laboratory conditions at the Pharmaceutical Chemistry Department of the ZSMU. The film-forming compositions of the Opadry brand in various concentrations, the Glatt apparatus for applying the film-forming coating were used; the volume of the drum was 0,8L at 400 g of loading mass. 3% of the film-forming agent was applied to the core tablets.

Results and discussion. According to the fact that the film-forming coatings at the same concentration provide different viscosity, the recommended by Colorcon manufacturer were used for the experiment: 15% suspension for coating with HPMC, 20% and 30% suspension for PVD coating. Each series of obtained tablets was evaluated in: appearance, uniformity of mass, resistance to crushing, disintegration. The dispersion analysis of the experimental data of the coated L-arginine with thiotriazolin tablets showed, that OPADRY is the best of the five types of film-forming systems.

Conclusion: Conducted research on the choice of film-forming system for coating of core L-arginine with thiotriazoline tablets by protective polymeric film. According to the obtained indicators - the appearance of the film, the uniformity of coated tablets mass, their resistance to crushing and the disintegration, it is rational to use the15% film-forming OPADRY suspension.