RESEARCH OF THE EFFECT OF A POTENTIAL MEDICINAL PRODUCT WITH ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY ON STRUCTURAL CHANGES IN THE VAGINAL MUCOSA ON THE MODEL OF TRAUMATIC VAGINITIS

Authors

DOI:

https://doi.org/10.11603/2312-0967.2019.1.9881

Keywords:

traumatic vaginitis, structural changes, mucous membrane, suppositories

Abstract

The aim of the work. Exploring structural changes in the mucous membrane of the vagina of the rats after the simulation of traumatic vaginitis and the effect of the combined suppository with anti-inflammatory and antimicrobial activity.

Materials and Methods. Animals reproduced the model of traumatic vaginitis, after which the investigated drugs were introduced into the vagina in the form of a suppository. The investigated potential medicinal product contained ibuprofen, clotrimazole and metronidazole in the form of suppositories. Neo-Penotran® (Comparative Preparation) in its composition had miconazole and metronidazole. Both drugs included an identical basis – witepsol. The study material was the samples of the vagina of the rats, which were selected for histological examination.

Results and Discussion. In the simulation of traumatic vaginitis in rats, dystrophic changes in epithelial cells and a decrease in the thickness of the vaginal mucosa, vascular hyperemia, leukocyte infiltration, and, to a lesser extent, regeneration were observed. The introduction of the investigated potential medicinal product and the comparator product positively influenced the recovery processes of the vaginal mucus. The structural manifestations of the restorative process were proliferative changes in the epithelium and an increase in the density of fibroblasts in their own plate of the mucous membrane. A statistically significant increase in the thickness of the epithelium is established.

Conclusions. A conclusion is made on the prevention of dystrophic vaginal changes in the use of the investigational medicinal product and the comparison product on the model of traumatic vaginitis, the tread effect on the epithelium of the vaginal mucosa and the anti-inflammatory effect of ibuprofen in combination with antimicrobial agents.

Author Biographies

L. V. Onyshchuk, Bogomolets National Medical University

assistant of the department of  Pharmaceutical, Biological and Toxicological Chemistry

I. V. Nizhenkovska, Bogomolets National Medical University

Doctor of Medicine, Professor, Head of the department of  Pharmaceutical, Biological and Toxicological Chemistry

S. I. Savosko, Bogomolets National Medical University

PhD (Doctor of Philosofy), assistant of the department of histology and embryology

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Published

2019-03-07

How to Cite

Onyshchuk, L. V., Nizhenkovska, I. V., & Savosko, S. I. (2019). RESEARCH OF THE EFFECT OF A POTENTIAL MEDICINAL PRODUCT WITH ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY ON STRUCTURAL CHANGES IN THE VAGINAL MUCOSA ON THE MODEL OF TRAUMATIC VAGINITIS. Pharmaceutical Review Farmacevtičnij časopis, (1), 97–103. https://doi.org/10.11603/2312-0967.2019.1.9881

Issue

No. 1 (2019)

Section

Pharmacological researches of biologically active substances

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