DEVELOPMENT OF COMPOSITION AND TECHNOLOGY THE TOOTHPASTE WITH METHYLSALICYLATE

Authors

DOI:

https://doi.org/10.11603/2312-0967.2019.1.9876

Keywords:

dental plaque, toothpaste, methyl salicylate, oral cavity

Abstract

The aim of the work. Development of the composition and technology of a new toothpaste with methylsalicylate.

Materials and Methods. Methods of information search, analysis of literature data and experimental research have been used.

Results and Discussion. As the active pharmaceutical ingredient of the proposed toothpaste, methylsalicylate is used because it exhibits antimicrobial, analgesic and anti-inflammatory effects. The optimal composition of the toothpaste has been determined on the basis of own experimental studies: sodium carboxymethyl cellulose – gel formulation, calcium carbonate – abrasive component, saccharin – flavor coriander, sodium bicarbonate – softener and regulator of alkaline-acid balance, glycerol – volatile carrier, menthol – flavor, water – a solvent.

Conclusion. The development of a toothpaste with methyl salicylate is not only an extension of the range of hygiene products – it is an improved approach to restoring micro biocenosis, the ability to more thoroughly clean teeth from the raging and breath freshening, which is important in the daily care of the oral cavity.

Author Biographies

I. S. Hrynovets, Danylo Halytsky Lviv National Medical University

PhD, associate professor, the Drug technology and biopharmaceutics department

T. A. Shostak, Danylo Halytsky Lviv National Medical University

PhD, assistant, the Drug technology and biopharmaceutics department

Yu. V. Yaremyshyn, Danylo Halytsky Lviv National Medical University

student of the fifth year of study, Pharmaceutical Faculty

V. S. Hrynovets, Danylo Halytsky Lviv National Medical University

PhD, associate professor, the Therapeutic Dentistry department

References

Brandt FS, Cazzaniga A, Hann M. Cosmeceuticals: current trends and market analysis. Semin Cutan Med Surg. 2011;30(3): 141-3.

Danilevskiy MF, Borisenko AV. Periodontal disease. [Заболевания пародонта] Kyiv “Zdorovia”; 2000. Russian.

Reszko AE, Berson D, Lupo MP. Cosmeceuticals: practical applications. Obstet Gynecol Clin North Am. 2010;37(4): 547-69.

Dmitriyeva LA., Krayneva AG. [Modern ideas about the role of microflora in the pathogenesis of periodontal disease]. Parodontologiya. 2004;1(30): 8-15.

Methyl salicylate / PubChem Compound Summary for CID 4133 [open chemistry database]. Available at: https://pubchem.ncbi.nlm.nih.gov/compound/methyl_salicylate#section=Top

GOST 7983-99 “Tooth paste”. [ГОСТ 7983-99 “Зубна паста”] [Electronic source]. Available at: http://docs.cntd.ru/document/1200006990. Ukrainian.

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Published

2019-03-07

How to Cite

Hrynovets, I. S., Shostak, T. A., Yaremyshyn, Y. V., & Hrynovets, V. S. (2019). DEVELOPMENT OF COMPOSITION AND TECHNOLOGY THE TOOTHPASTE WITH METHYLSALICYLATE. Pharmaceutical Review Farmacevtičnij časopis, (1), 58–63. https://doi.org/10.11603/2312-0967.2019.1.9876

Issue

No. 1 (2019)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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