MODERN APPROACHES TO USE EMULATORS AND CONSERVATIVES IN THE COMPOSITION OF DERMATOLOGICAL DRUGS

Authors

  • I. R. Pelekh Danylo Halytsky Lviv National Medical University
  • S. B. Bilous Danylo Halytsky Lviv National Medical University

DOI:

https://doi.org/10.11603/2312-0967.2018.3.9453

Keywords:

emulsifiers, antimicrobial preservatives, surfactants, emulsions, medicines, medicinal cosmetics

Abstract

The aim of the work.  Study the nomenclature of emulsifiers and antimicrobial preservatives, used in modern semi-solid drugs, data analysis of scientific literature on the development of new drugs emulsion type. 

Materials and Methods.  Methods of information retrieval and analysis of literature data are used. 

Results and Discussion.  To date, a large number of dermatological preparations are medicines of emulsion type with a high content of the water phase – these are semi-solid preparations for the skin and medicinal cosmetic creams. In the manufacture of emulsion preparation, it is important to select the auxiliary substances, in particular emulsifiers and antimicrobial preservatives, which are mainly surfactants by their structure, and often cause side reactions.  Practically all synthetic surface-active substances can remove all fatty products from the body surface, in particular a thin protective film that forms sebaceous and sweat glands of the skin.  Therefore, it is promising to use biogenic surfactants as emulsifiers and preservatives.  The study of the range of emulsifiers and antimicrobial preservatives used in semi-solid emulsion registered in the State Register of Medicinal Products of Ukraine was conducted.  As a result of the study, it was found that polysorbates are mainly used as emulsifiers of the 1st kind and cetostearyl alcohol and lanolin as emulsifiers of the 2nd kind in emulsion medicines.

 Conclusions.  Considering that synthetic surfactants can cause significant adverse reactions and are strong allergens, it is relevant to study biogenic surfactants as promising emulsifiers and antimicrobial preservatives, to establish their emulsion and preservation ability, which will facilitate the expansion of the range of excipients for emulsion medicines and cosmetics.

Author Biographies

I. R. Pelekh, Danylo Halytsky Lviv National Medical University

postgraduate student of the Department of drug technology and biopharmaceutics

S. B. Bilous, Danylo Halytsky Lviv National Medical University

PhD (Doctor of Philosofy), associate professor, Head of the Department of drug technology and biopharmaceutics

References

Walters Y. Dermatologic, cosmeceutic and cosmetic development. 2008.

Walters K. Dermatological and transdermal formulations. New-York-London; 2007.

Kalyniuk TH, Bokshan YeV, Bilous SB. Practice on technology of medicinal cosmetics. [Практикум з технології лікарських косметичних засобів] Kyiv: Meditsyna; 2008. Ukrainian.

Ruban OA, Pertsev IM, Kutseko SA, Maslii, YuS. Substances in the manufacture of medicines: a manual for students of higher pharmaceutical educational institutions [Допоміжні речовини у виробництві ліків: навч. посіб.для студентів вищ.фармац. навч. закл.]. Kharkiv: Zoloti storinky; 2016. Ukrainian.

Hladukh YeV, Ruban OA, Saiko IV. Industrial technology of drugs: textbook for the students of pharmacy specialties of higher educational institutions [Промислова технологія лікарських засобів: Підручник для студ. фармац. спец. вищ. навч. закл.]. Kharkiv: NFaU Oryhinal; 2016. Ukrainian.

Voronov SA, Stetsyshyn YuB, Panchenko YuV, Vasyliev VP. Toxicological chemistry of food products and cosmetics [Токсикологічна хімія харчових продуктів та косметичних засобів]. Lviv: Vydavnytstvo Lvivskoi politekhniky; 2010. Ukrainian.

Karpenko OV, Martyniuk NV, Shulha OM, Pokynbroda Tia, Vildanova RI, Shchehlova NS, inventors; Surface active bioproduct. UA N71792 A, 15. MPK S12 No. 1/02, C12 R 1:38 (Patent) 2004 Dec 25. Ukrainian.

Parkinson M. Biosurfactants. Biotech Advs. 1985;3: 65-83.

Sim L, Ward OP, Li Z. Production and characterization of a biosurfactant isolated from Pseudomonas aeruginosa UW-1. J Ind Microbiol Biotechnol. 1997;19: 232-8.

State Register of Drugs of Ukraine [Державний реєстр лікарських засобів України]. Available from: http://www.drlz.kiev.ua/. Ukrainian.

Yarema OI, Fedorovska MI, Polovko NP. [Development of emulgel technology with Saw Palmetto extract and Japanese Sophora tincture for androgenic alopecia treatment]. Farm Zhurn. 2016;5: 50-6. Ukrainian.

Khomenko OI, Budishevska OG, Varvarenko SM. [Amphiphilic surface active substances based on promelite dianghidride as emulsifiers of emulsion polymerization]. Voprosy khimii i khimicheskoy tekhnolohii. 2012;4: 40-6. Ukrainian.

Yarema OI, Fedorovska MI. [Development of emulsion basis for the creation of medicinal cosmetic product for use in androgenic alopecia]. Visnyk farmatsii. 2014;2(78): 15-9. Ukrainian.

Mishchenko OI, Tykhonov OI. [Study of the influence of emulsifiers on the rheological properties of a combined semi-solid dosage form of chondroprotective action]. Visnyk farmatsii. 2011;3(67): 3-7. Ukrainian.

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Published

2018-10-19

How to Cite

Pelekh, I. R., & Bilous, S. B. (2018). MODERN APPROACHES TO USE EMULATORS AND CONSERVATIVES IN THE COMPOSITION OF DERMATOLOGICAL DRUGS. Pharmaceutical Review Farmacevtičnij časopis, (3), 52–57. https://doi.org/10.11603/2312-0967.2018.3.9453

Issue

No. 3 (2018)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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