STUDY OF QUANTITATIVE FACTORS ON TECHNOLOGICAL PROPERTIES OF COMPRESSION MIXTURE AND TABLETS OF ROUND-LEAVED WINTERGREEN EXTRACT
DOI:
https://doi.org/10.11603/2312-0967.2018.3.9377Keywords:
tablet, technological parameters compression mixture, vegetable extracts, pyrola rotundifolia, round-leaved wintergreen, mathematical planning of the experimentAbstract
The aim of the work. Investigation of the influence of quantitative factors on the pharmacological and technological properties of compression mixture and tablets on the basis of dry extract from round-leaved wintergreen.
Materials and Methods. The study of the influence of the 7 quantitative factors on the properties of the compression mixture and the tablets of round-leaved wintergreen leaf were carried out using the random balance method. The following indicators of quality of compression mixture and tablets were studied: flowability, free bulk density, bulk density after shrinkage, Kara index, appearance, mass homogeneity, disintigration, strength, erasing, desirability function.
Results and Discussion. Studies conducted using the method of random balance showed that to a large extent, the fluidity of the compression mixture depended on the amount of flovlacs: with its increase, the tablet mass flowed faster and neusilin US 2, magnesium stearate, with increasing the flow of which decreases.
When decreasing the amount of neusilin US 2 in the tablet, the deviation from the average mass declined. With the addition of from round-leaved wintergreen extracts, large amounts of sodium carboxymethylstarch, tabletose 80 and magnesium stearate, the value of this indicator improved.
The most significant effect on strength of the tablets was the decrease in the number of tabletose 80, which resulted in the tablets becoming stronger.
The greatest influence on the erosion of the tablets, with a small amount of sodium croscarmellose, with the increase of which the index has increased.
In the study of the disintigration of tablets, it was found that a decrease in the number of neusilin US2, prosolv EASY tab SP, and magnesium stearate in tablets led to a reduction in their disintigration.
Conclusions. The influence of the amounts of substances on the technological indicators of the quality of the compression mixture and the tablets with round-leaved wintergreen extract was determined. In the process of research, the function of desirability, as a generalized indicator of the quality of compression mixture and tablets, has been used. The results of the studies allowed selecting the following excipients for further research: neusilin US 2, prosolv EASY tab SP, sodium croscarmellose, tabletose 80 and magnesium stearate.
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