BLACK CURRANT FRUITS PROSPECTIVE RAW MATERIAL FOR THE DEVELOPMENT OF NATIONAL MONOGRAPH TO STATE PHARMACOPOEIA OF UKRAINE

Authors

  • V. Yu. V. Kuznietsova National University of Pharmacy, Kharkiv
  • A. G. Kotov Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines, Kharkiv
  • V. S. Kyslychenko National University of Pharmacy, Kharkiv
  • E. E. Kotova Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines, Kharkiv

DOI:

https://doi.org/10.11603/2312-0967.2018.2.8994

Keywords:

black currant fruits, State Pharmacopeia of Ukraine.

Abstract

The aim of the work. Сarrying out a comparative analysis of the parameters of the standardization of black currant fruit and defining approaches to the development of national monographs "Black currant dry fruits" and " Black currant fresh fruits".

Materials and Methods. We compared parameters of standardization from British Pharmacopoeia, State standard 21450-75 “Black currant fruits” and State standard 6829-89 “Black currant fresh fruits”. The analysis was conducted on the following indicators: title of the article, definitions, requirements for the content of biologically active substances, identification by macroscopic and microscopic characteristics, indexes, quantitative determination.

Results and Discussion. It was found that it is not entirely correct to compare the standard criteria, one of which is developed for the food industry, and the other for standardization of medicinal plant material. In addition, both standards have not been reviewed for more than 25 years. The monograph of British Pharmacopeia gives only a few modern criteria (macroscopic and microscopic characteristics of raw materials) for the standardization of fresh black currant fruits. At the same time, all documents do not contain identification and determination of content of biologically active substances.

Conclusions. Analysis of literary sources indicates the presence in the fruits of black currant a different groups of biologically active substances that have a wide range of pharmacological activity. Modern methods of standardization of black currant fruits are absent. The development of national monographs on fresh and dried black currant fruits is an actual problem.

Author Biographies

V. Yu. V. Kuznietsova, National University of Pharmacy, Kharkiv

National University of Pharmacy, Kharkiv

A. G. Kotov, Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines, Kharkiv

Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines, Kharkiv

V. S. Kyslychenko, National University of Pharmacy, Kharkiv

National University of Pharmacy, Kharkiv

E. E. Kotova, Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines, Kharkiv

Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines, Kharkiv

References

Kotov AH. [Rules and the procedure for the development of monographs on medicinal plant raw materials. Part 1-a]. Upravl. ekonom. Ta zapezpech. yakosti v farmatsii. 2011;6(20):6-22. Ukrainian.

Kotov AH. [Rules and the procedure for the development of monographs on medicinal plant raw materials. Part 2-a]. Upravlinnia, ekonomika ta zapez. yakosti v farmatsii. 2012:1(21):4-10. Ukrainian.

State register of varieties suitable for distribution in Ukraine for 2018. Available from: [http://minagro.gov.ua/uk/ministry?nid=21767]

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Mattila PH, Hellstrom J, McDougall G, Dobson G, Pihlava JM. Polyphenol and vitamin C contents in European commercial blackcurrant juice products. Food Chem. 2011;127:1216-23.

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State standard 21450-75: Fruits of black currant. Interstate Standard [Плоды черной смородины. Межгосударственный стандарт]. Introduced by a resolution of the State Committee of Standards of the Council of Ministers of the USSR 31.12.1975 № 4124. Russian.

State standard 6829-89: Black currant fresh. Requirements for procurement, supply and sale [Смородина черная свежая. Требования при заготовках, поставках и реализации]. Moscow: Publishing house of standards. 1989. 4 p. Russian.

British Pharmacopoeia 2012. Available from: [http:// bp2012.infostar.com.cn/Bp2012.aspx?a=display&id=8173]

State Pharmacopoeia of Ukraine: in 3 vol. / State Enterprise «Ukrainian Research Center expert pharmacopoeia quality medicines.» – 2nd ed. – Kharkiv State Enterprise “Ukrainian Research Center expert pharmacopoeia drug quality”, 2015;1:1128. Ukrainian.

Lenchyk LV, Kotov AH, Kyslychenko VS. [Bird cherry fruits are perspective materials for preparing a monograph in the Ukrainian Pharmacopoeia]. Pharmaceutical Review. 2016;2:75-79. Ukrainian.

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Published

2018-06-21

How to Cite

V. Kuznietsova, V. Y., Kotov, A. G., Kyslychenko, V. S., & Kotova, E. E. (2018). BLACK CURRANT FRUITS PROSPECTIVE RAW MATERIAL FOR THE DEVELOPMENT OF NATIONAL MONOGRAPH TO STATE PHARMACOPOEIA OF UKRAINE. Pharmaceutical Review Farmacevtičnij časopis, (2), 11–16. https://doi.org/10.11603/2312-0967.2018.2.8994

Issue

No. 2 (2018)

Section

Phytochemical researches

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