PHARMACOEPIDEMIOLOGICAL ANALYSIS OF TRENDS IN THE CONSUMPTION OF BETA-LACTAM ANTIBIOTICS FOR THE TREATMENT OF PNEUMONIA IN THE REPUBLIC OF TAJIKISTAN
DOI:
https://doi.org/10.11603/2312-0967.2017.2.7910Keywords:
community-acquired pneumonia, antibiotics, pharmacoepidemiological analysis.Abstract
The aim of the work. Сonducting a retrospective analysis of the consumption of β-lactam antibiotics for the treatment of community-acquired pneumonia in hospitals in the Republic of Tajikistan using the DDD methodology.
Materials and Methods. The consumption of β-lactam antibiotics was estimated according to the WHO ATC/DDD index for 2011–2015. The unit of measurement used was the number of grams of the active substance, followed by calculation of the total DDDs, DDD / 100 bed-days and % of total DDDs.
Results and Discussion. A retrospective analysis of the consumption of β-lactam antibiotics for the treatment of communityacquired pneumonia in the Pulmonology Department of the Multidisciplinary Hospital of the Republic of Tajikistan was conducted. An increase in the consumption of β-lactam antibiotics for the treatment of pneumonia in 2011–2015 was established. The dynamics was determined exclusively due to an increase in the consumption of antibacterial drugs from the group of cephalosporins, namely cephalosporin of the third generation - ceftriaxone. At the same time interest in the quality of antibacterial drugs for the treatment of community-acquired pneumonia to antimicrobial drugs from the penicillin group decreased.
Conclusions. There is a gradual reduction in the use of obsolete ineffective penicillin preparations (ampicillin) for pharmacotherapy of community-acquired pneumonia and an unjusti ed reduction in consumption of one of the most effective and safe antibiotics – amoxicillin. There is a decrease in the consumption of rst-generation cephalosporins (cefazolin). In this case, the great popularity of ceftriaxone, carries the potential danger of increasing resistance to this drug and the development of adverse reactions, which requires more careful monitoring of the rationality of the use of this antibiotic.
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