THE STUDY OF STABILITY AND DETERMINATION OF THE STORAGE CONDITIONS AND THE SHELF LIFE OF THE OINTMENT “ESTAN”
DOI:
https://doi.org/10.11603/2312-0967.2017.2.7908Keywords:
ointment, геморрой, quality fi gures, storage requirements, stability.Abstract
The aim of the work. To study stability of the ointment “Estan” in the process of storage and determine the storage conditions and its shelf life.
Materials and Methods. The study object was the ointment “Estan” containing lidocaine hydrochloride and the extract of oak bark and horse chestnut seed in the hydrophilic polyethylene oxide base for treating hemorrhoid. During storage of the samples of the ointment we studied such indicators as appearance, uniformity, the weight of the container content and its integrity, рН, particle size, the quantitative content of tannin, escin, lidocaine hydrochloride, and preservatives, microbiological purity were determined by physical, physicochemical, microbiological and pharmacotechnological methods according to the requirements of the State Pharmacopoeia of Ukraine (SPhU).
Results and Discussion. The results of the conducted studies showed that the ointment “Estan” is stable when stored in a dry cool place protected from light for 2 years. The storage at room temperature resulted in an insignifi cant pH increase.
Conclusions. The study of stability of the ointment “Estan” for treating hemorrhoid in the process of storage was conducted. It was experimentally proven that all indicators of the product quality meet the requirements of the draft for quality control methods. The storage conditions for the ointment “Estan”, namely in a dry dark cool place for 2 years, were determined.
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