CHOOSING QUANTITIES OF EXCIPIENTS FOR THE DEVELOPMENT OF CAPSULES WITH THICK EXTRACT OF CREEPING THYME BY USING REGRESSION ANALYSIS

Abstract

The aim of the work. Choosing of quantities of excipients for the preparation of the powder mass on the basis of thick extract of creeping thyme.

Materials and Methods. Thick extract of creeping thyme, which received thickening in rotary evaporator LABOROTA 4001 at 80° C of liquid extract of creeping thyme. Research quantities of excipients in developing of powder mass with thick creeping of thyme extracts was performed by using regression analysis (the symmetrical composition rototabel uniform plan of the second order).

Results and Discussion. We studied the effect of quantitative factors and established the relationship between them by using regression equations. It was found that increasing the number of neuselin UFL 2 has positive effect on the rate of flow through the nozzle, while increasing the number of sodium croscarmellose increases the value of bulk density of the mixture before and after shrinkage and signiflcantly reduces the angle of repose. Providing canonical form for equation regression analysis and conducting line of level output we obtained the optimal composition of powder mass with thick extract of creeping thyme.

Conclusion. We proposed the content of powder mixture with thick extract of creeping thyme: thick extract of creeping thyme (the dry residue - 80 %) in terms of dry - 0,075 g, neuselin UFL 2 - 0.02 g, sodium croscarmellose - 0.022 g, MCC 101 - 0,078 g.