COMPARATIVE ANALYSIS OF TABLETS OF DIFFERENT SERIES AND REFERENCE DRUG ON THE GROUND OF THE SUBSTANCE ADEMETIONINE 1,4-BUTANDISULFONATE BY INFRARED SPECTROSCOPY

Authors

  • K. S. Burdak JSC «Farmak», Kyiv, Ukraine
  • T. H. Yarnyh National University of Pharmacy, Kharkiv, Ukraine
  • M. I. Borshchevska JSC «Farmak», Kyiv, Ukraine
  • I. B. Yanchuk JSC «Farmak», Kyiv, Ukraine

DOI:

https://doi.org/10.11603/2312-0967.2016.2.6657

Keywords:

аdemetionine 1, 4-butandisulfonatе, infrared spectroscopy, humidity environment, hygroscopic substance.

Abstract

Introduction

Infrared analysis – is a universal physial method that is applied in the research of structural features of different organic and inorganic compounds. Its peculiarity is possibility to carry out the research without previous sample processing that is very important during the work with moisture-retentive chemicals. During the molecule is irradiated by infrared light only those quanta are absorbed frequency of which agree with frequency of valence, deformational and vibrational motion of the molecules [2,3].

Investigation methods

Were studied: lot 20515 (pattern №1 that was got under the environmental humidity of 15%), lot 10314 (pattern №2, environmental humidity 20%), lot 10513 (pattern №3, environmental humidity 30%) and lot 11113 (pattern №4, environmental humidity 40%).

Received pills were being investigated with the help of absorption infrared spectroscopy (AIR spectroscopy) in the intermediate infrared band (4000-400 cm-1). During the researches apparatus Thermo Nicolet IS50 with ATR module.

Results and discussions

This way, in accordance with the results of our researches the mechanisms  of transformation of  ademetionine structure under the influence of water or –OH groups. Received data confirm that optimized climatic conditions for the production of pills on the basis of the substance ademetionine 1,4 butandisulfonate is environmental humidity not higher than 20%, and the temperature 20 °С.

Conclusions

  1. Comparative analysis of ademetionine 1,4 butandisulfonate pills of different series and reference listed drug   «Heptral»  was carried out with the help of infrared spectroscopy.
  2. It is shown that infrared absorption spectroscopy as operational method of the analysis allows to study the influence of the humidity on structural-informative qualities of the substance ademetionine 1,4 butandisulfonate in developing preparations.
  3. It’s experimentally determined and confirmed that optimized climatic parameters of getting pills, environmental humidity not higher than 20% and the temperature 20°С.

Author Biographies

K. S. Burdak, JSC «Farmak», Kyiv, Ukraine

JSC «Farmak», Kyiv, Ukraine

T. H. Yarnyh, National University of Pharmacy, Kharkiv, Ukraine

National University of Pharmacy, Kharkiv, Ukraine

M. I. Borshchevska, JSC «Farmak», Kyiv, Ukraine

JSC «Farmak», Kyiv, Ukraine

I. B. Yanchuk, JSC «Farmak», Kyiv, Ukraine

JSC «Farmak», Kyiv, Ukraine

References

Issledovanie fiziko-himicheskih vzaimodeystviy v tverdoy faze mezhdu komponentami preparatov analgeziruyuschego, protivovospalitelnogo i zharoponizhayuschego deystviya na osnove paratsetamola / N. O.Eltsova, G. B. Golubitskiy, E. V. Budko, O. I. Izosimin. // Mezhdunarodnyiy zhurnal prikladnyih i fundamentalnyih issledovaniy. – 2014. – N 3. – S. 118–123.

Identification of anisodamine tablets by Raman and near-infrared spectroscopy with chemometrics / [L. Li, J. Li, H. Zang та ін.]. // Spectrochimica Acta Part A: Molecular Spectroscopy. – 2015. – №127. – С. 91 – 97.

Chaveza P. Active content determination of pharmaceutical tablets using near infrared spectroscopy as Process Analytical Technology tool / P. Chaveza, P. Sacréa. // Talanta. – 2015. – №144. – С. 1352–1359.

Frank S. Identification of a pharmaceutical tablet’s origin using FT Near-IR and Principal Component Analysis / S. Frank, M. S. Weston. // Agilent Technologies. – 2011. – С. 1–10.

Priboryi dlya farmatsevticheskogo analiza. // Farmatsevticheskaya otrasl. – 2012. – N 4. – S. 104–106.

Downloads

Published

2016-07-08

How to Cite

Burdak, K. S., Yarnyh, T. H., Borshchevska, M. I., & Yanchuk, I. B. (2016). COMPARATIVE ANALYSIS OF TABLETS OF DIFFERENT SERIES AND REFERENCE DRUG ON THE GROUND OF THE SUBSTANCE ADEMETIONINE 1,4-BUTANDISULFONATE BY INFRARED SPECTROSCOPY. Pharmaceutical Review Farmacevtičnij časopis, (2), 32–34. https://doi.org/10.11603/2312-0967.2016.2.6657

Issue

No. 2 (2016)

Section

Analysis of drugs

License

The authors who publish their materials in this journal agree with the following terms:

  • Authors reserve the right to authorship of their work and assign to the journal the right to first publish this work under the terms of the Creative Commons Attribution License, which allows other persons to freely distribute the published work with a mandatory reference to the authors of original work and the first publication of work in this journal Результат пошуку зображень за запитом "CC-BY logo".
  • Authors have the right to make independent extra-exclusive work agreements in the form they are published by this journal (for example, posting work in an electronic repository of an institution or publishing as part of a monograph), provided that the link to the first publication of the work in this journal is maintained.

Journal policy allows and encourages publication of manuscripts on the Internet (for example, in institutions repositories or on personal websites), both before the publication of this manuscript and during its editorial review, as it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the citation of the published work (see The Effect of Open Access).