QUALITY CONTROL AND STANDARDIZATION OF MEDICAL PENCILS CONTAINING WALNUT OIL
DOI:
https://doi.org/10.11603/2312-0967.2026.1.15992Keywords:
quality control, standardization, medical pencils, semi-solid dosage forms, walnut oil, stability, quality attributes, pharmacopoeial testsAbstract
ABSTRACT
Medical pencils are a topical dosage form used for the treatment and prevention of skin and mucosal disorders. The assessment of their quality is essential to ensure safety and consistent performance. Despite the availability of pharmacopoeial recommendations for semi-solid dosage forms, issues related to the quality control and standardization of medical pencils containing natural oils remain relevant.
The aim of the study was to perform quality control of medical pencils containing walnut oil and to substantiate approaches to their standardization in order to confirm the stability of the formulation and its safety during storage and use.
Materials and methods. The study objects were medical pencils containing walnut oil. Organoleptic, physical, physicochemical, microscopic, and statistical methods were applied.
Results and discussion. Based on the results of the conducted studies, the standardization parameters of the medical pencils were established: organoleptic (appearance, color, odor, consistency), pharmaco-technological (mass uniformity of the single-dose medicinal product, softening time, disintegration time, content uniformity), physical and physicochemical parameters (melting point, pH, acid value, and peroxide value). It was experimentally demonstrated that the medical pencils containing walnut oil remained stable over an 18-month storage period and showed no changes in the above-mentioned parameters.
Conclusions. Quality control of the medical pencils was carried out according to organoleptic, physical, physicochemical, and microscopic parameters. The stability of the proposed formulation was experimentally confirmed over 18 months of storage.
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Accepted 2026-03-08
Published 2026-03-31
