DEVELOPMENT OF THE COMPOSITION OF WALNUT OIL-BASED MEDICAL PENCILS

Authors

DOI:

https://doi.org/10.11603/2312-0967.2025.3.15576

Keywords:

skin damage, medical pencils, walnut oil, excipients

Abstract

The aim of the work - development of the composition of walnut oil-based medical pencils.

Materials and Methods. The research мaterials include walnut oil, beeswax, paraffin, cocoa butter, anhydrous lanolin, macrogol-400. Organoleptic, structural-mechanical and physical research methods were used during the work.

Results and Discussion. When developing the composition of medical pencils for healing shallow skin injuries, walnut oil was chosen as the active pharmaceutical ingredient, the medicinal properties of which are good due to the presence of various groups of biologically active substances (fatty acids, tocopherols, vitamins, carotenoids, etc.). The choice of excipients was important in developing the dosage form. The components of the base of the medical pencils were as follws: thckeners - paraffin and beeswax; plasticizers - anhydrous lanolin and macrogol-400; a form-forming agent, thickener and emulsifier - cocoa butter. In order to extend the shelf life, a preservative and antioxidant farnesol was added. To improve the consumer characteristics of the medical pencils, a fragrance was added - the “Passion Fruit” flavoring. The resulting medical pencils were a cylindrical shape, cream color, and a pleasant odor.

Conclusions. As a result of the research, the composition of walnut oil-based medical pencils was the theorethically and  experimentally substantiated.

Author Biographies

N. I. Dubel, Ivano-Frankivsk National Medical University

PhD (Pharmacy), Associate Professor, Department of Pharmaceutical Management, Drugs Technology and Pharmacognosy

L. M. Grytsyk, Ivano-Frankivsk National Medical University

Candidate of Pharmaceutical Sciences (PhD), Associate Professor Department of Chemistry, Pharmaceutical Analysis and Postgraduate Education

A. R. Grytsyk A. R., Ivano-Frankivsk National Medical University

DSc (Pharmacy), Рrofessor, Department of Pharmaceutical Management, Drugs Technology and Pharmacognosy

N. I. Lehin, Ivano-Frankivsk National Medical University

Candidate of Pharmaceutical Sciences (PhD), аssistant Department of Pharmaceutical Management, Drugs Technology and Pharmacognosy

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Published

2025-09-30

How to Cite

Dubel, N. I., Grytsyk, L. M., Grytsyk A. R., A. R., & Lehin, N. I. (2025). DEVELOPMENT OF THE COMPOSITION OF WALNUT OIL-BASED MEDICAL PENCILS. Pharmaceutical Review Farmacevtičnij časopis, (3), 27–34. https://doi.org/10.11603/2312-0967.2025.3.15576

Issue

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology