DEVELOPMENT OF THE COMPOSITION OF WALNUT OIL-BASED MEDICAL PENCILS
DOI:
https://doi.org/10.11603/2312-0967.2025.3.15576Keywords:
skin damage, medical pencils, walnut oil, excipientsAbstract
The aim of the work - development of the composition of walnut oil-based medical pencils.
Materials and Methods. The research мaterials include walnut oil, beeswax, paraffin, cocoa butter, anhydrous lanolin, macrogol-400. Organoleptic, structural-mechanical and physical research methods were used during the work.
Results and Discussion. When developing the composition of medical pencils for healing shallow skin injuries, walnut oil was chosen as the active pharmaceutical ingredient, the medicinal properties of which are good due to the presence of various groups of biologically active substances (fatty acids, tocopherols, vitamins, carotenoids, etc.). The choice of excipients was important in developing the dosage form. The components of the base of the medical pencils were as follws: thckeners - paraffin and beeswax; plasticizers - anhydrous lanolin and macrogol-400; a form-forming agent, thickener and emulsifier - cocoa butter. In order to extend the shelf life, a preservative and antioxidant farnesol was added. To improve the consumer characteristics of the medical pencils, a fragrance was added - the “Passion Fruit” flavoring. The resulting medical pencils were a cylindrical shape, cream color, and a pleasant odor.
Conclusions. As a result of the research, the composition of walnut oil-based medical pencils was the theorethically and experimentally substantiated.
References
Tarasenko VO, Davtyan LL, Volokh DS, Kuchmistova OF. et al. Highlighting certain aspects of remedies for treating wounds and wound infection: a historical-evolutionary approach. Phytotherapy. Journal. 2020;2: 43-47. DOI:10.33617/2522-9680-2020-2-43 DOI: https://doi.org/10.33617/2522-9680-2020-2-43
Guo JW, Jee SH. Strategies to Develop a Suitable Formulation for Inflammatory Skin Disease Treatment. Int J Mol Sci. 2021;4;22(11): 6078. DOI:10.3390/ijms22116078. DOI: https://doi.org/10.3390/ijms22116078
Tarasenko VO. Scientific, practical and experimental justification of the composition and technology of antimicrobial drugs with anesthetic action for the needs of the medical service of the Armed Forces of Ukraine: dissertation for the degree of Doctor of Pharmacy: specialty 15.00.01 "Drug technology, organization of pharmaceutical business and forensic pharmacy". 2021;K.: 513.
Nesteruk TM, Polovko NP. Justification of the composition of a medical pencil for the prevention and treatment of skin diseases and red border of the lips. Journal of Pharmacy. 2022;2(104): 26-31. DOI: 10.24959/nphj.22.95 DOI: https://doi.org/10.24959/nphj.22.95
Shulga LI, Rolik-Attia SM, Gubchenko TD, Piminov OF. Study of the stability of an extemporaneous medicinal product in the form of medical pencils. Modern aspects of the creation of extemporaneous allopathic, homeopathic and cosmetic medicinal products: collection of scientific works X.: National University of Physics and Technology. 2021;6: 100-101.
Nesteruk TM, Polovko NP. Prospects for the creation of medical pencils with oil extracts. Modern achievements of pharmaceutical technology and biotechnology: collection of scientific works. Kharkiv: Publishing house of the National University of Physics and Technology. 2019;6: 361-365.
Dovga IM, Minukhin VV, Ivannik VY et al. Determination of antimicrobial properties of a local combined medicinal product based on walnut extract. International Journal of Education and Science. 2020;3(1): 42-48. DOI: 10.26697/ijes.2020.1.4 DOI: https://doi.org/10.26697/ijes.2020.1.4
Zalygina EV, Podpletnya OA. The relevance of developing domestic herbal medicines from walnut. Phytotherapy. Journal. 2016;2: 29-31.
Song H, Cong Z, Wang C et al. Research progress on Walnut oil: Bioactive compounds, health benefits, extraction methods, and medicinal uses. J Food Biochem. 2022;46(12): e14504. DOI:10.1111/jfbc.14504. DOI: https://doi.org/10.1111/jfbc.14504
Gao P, Chang K, Wang S et al. Characterizing the Phenolic Compounds in Iron Walnut Oil (Juglans sigillata Dode) Across Chinese Regions. Foods. 2025;14(5): 899. DOI: 10.3390/foods14050899. DOI: https://doi.org/10.3390/foods14050899
Esselun C, Dieter F, Sus N, Frank J, Eckert GP.. Walnut Oil Reduces Aβ Levels and Increases Neurite Length in a Cellular Model of Early Alzheimer Disease. Nutrients. 2022;14(9): 1694. DOI: 10.3390/nu14091694. DOI: https://doi.org/10.3390/nu14091694
Gao P, Ding Y, Chen Z et al. Characteristics and Antioxidant Activity of Walnut Oil Using Various Pretreatment and Processing Technologies. Foods. 2022;11(12): 1698. DOI: 10.3390/foods11121698. DOI: https://doi.org/10.3390/foods11121698
Zhao D, Xiao J, Qiang L et al. Walnut ointment promotes full-thickness burning wound healing: role of linoleic acid. Acta Cir Bras. 2022;37(9): e370902. DOI: 10.1590/acb370902. DOI: https://doi.org/10.1590/acb370902
Demirel G, Sanajou S, Yirün A et al. Walnut oil: a promising nutraceutical in reducing oxidative stress and improving cholinergic activity in an in vitro Alzheimer's disease model. Toxicol Res (Camb). 2024;13(4): tfae097. DOI: 10.1093/toxres/tfae097. DOI: https://doi.org/10.1093/toxres/tfae097
Chen Q, Deng X, Qiang L et al. Investigating the effects of walnut ointment on non-healing burn wounds. Burns. 2020;47(2): 455-465. DOI: 10.1016/j.burns.2020.06.032. DOI: https://doi.org/10.1016/j.burns.2020.06.032
State Pharmacopoeia of Ukraine. 2nd ed. Supplement 4. Kh.: State Enterprise "Ukrainian Scientific Pharmacopoeial Center for the Quality of Medicinal Products". 2020: 600 p.
Shulga LI, Piminov OF, Beztsenna TS et al. Medicines in the form of medical pencils: characteristics, prospects for creation. Modern achievements of pharmaceutical technology and biotechnology: collection of scientific works. Kh., 2016: 707-710. [Electronic resource]. Available at: URL: https://dspace.nuph.edu.ua/bitstream/123456789/11657/1/707-710.pdf
European Pharmacopоeia 9.0 [9th edition] / European Directorate for the Quality of Medicines & HealthCare (EDQM). Strasbourg: Council of Europe, 2017. Available at: http://online6.edqm.eu/ep900
Drug Directory. Compendium Online [Electronic resource]. Access mode: https://compendium.com.ua/uk/
State Pharmacopoeia of Ukraine: 2nd ed. Kh.: State Enterprise "Ukrainian Scientific Pharmacopoeial Center for the Quality of Medicinal Products". 2014;2:724.
State Pharmacopoeia of Ukraine: 2nd ed. Kh.: State Enterprise "Ukrainian Scientific Pharmacopoeial Center for the Quality of Medicinal Products". 2014;2:724.
Derwin R, Patton D, Avsar P, Strapp H, Moore Z. The impact of topical agents and dressing on pH and temperature on wound healing: A systematic, narrative review. Int Wound J. 2022;19(6):1397-1408. DOI:10.1111/iwj.13733. DOI: https://doi.org/10.1111/iwj.13733
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Pharmaceutical Review / Farmacevtičnij časopis

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
The authors who publish their materials in this journal agree with the following terms:
- Authors reserve the right to authorship of their work and assign to the journal the right to first publish this work under the terms of the Creative Commons Attribution License, which allows other persons to freely distribute the published work with a mandatory reference to the authors of original work and the first publication of work in this journal
. - Authors have the right to make independent extra-exclusive work agreements in the form they are published by this journal (for example, posting work in an electronic repository of an institution or publishing as part of a monograph), provided that the link to the first publication of the work in this journal is maintained.
Journal policy allows and encourages publication of manuscripts on the Internet (for example, in institutions repositories or on personal websites), both before the publication of this manuscript and during its editorial review, as it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the citation of the published work (see The Effect of Open Access).