TECHNOLOGICAL AND BIOPHARMACEUTICAL RESEARCH IN THE CREATION OF A COSMETIC PRODUCT BASED ON THE PHYTO-SUBSTANCE OF SIBERIAN STATICE (LIMONIUM GMELINII)
DOI:
https://doi.org/10.11603/2312-0967.2025.1.15168Keywords:
cosmetic, phytosubstance of Siberian statice, pharmaco-technological properties, biopharmaceutical research, emulsifierAbstract
The aim of the work – to study the effect of emulsifiers on some pharmaco-technological properties of a cosmetic product based on the phytosubstance of Siberian statice; to conduct biopharmaceutical studies of the produced emulsion creams.
Materials and Methods. The study was conducted on various series of cosmetic products in the form of emulsion cream based on the active ingredient of the phytosubstance of Siberian statice. 6 emulsifiers were selected for the study, 2 of which were used as mono-emulsifiers and 4 – in combination with co-emulsifiers. The emulsions were obtained by the hot emulsification method. The study of the properties of the emulsion was carried out in accordance with the requirements of the State Pharmacopoeia of Ukraine and DSTU (National Standards of Ukraine) 4765:2007 “Cosmetic creams”.
Results and Discussion. The influence of excipients, namely emulsifiers, on the pharmaco-technological properties of emulsion creams was studied. The organoleptic characteristics, pH, thermal stability and colloidal stability, and the homogeneity of the composition were investigated using microscopy. Studies were also conducted to determine the type of emulsion by staining. Based on the above studies, the best series were selected, for which biopharmaceutical studies were conducted.
Conclusions. The influence of emulsifiers on the pharmaco-technological properties of emulsion creams based on Siberian statice was analyzed. Based on the conducted studies, 5 series of the cosmetic product with satisfactory pharmacotechnological properties were selected, namely, cosmetics based on mono-emulsifiers Sepiplus-400, Montanov-68 and emulsifiers Montanov L, Planta M, Emulpharma, Easynov as co-emulsifiers. The selected series were subjected to biopharmaceutical analysis using the agar plate method, and the rate of release of the active substance from the cosmetic products was determined. It was established that series 1.1, 1.3, 2.1, 2.2 have good penetration of phenolic compounds into the agar gel. The series with such emulsifiers as Sepiplus-400, Montanov-68, which were used as mono-emulsifiers, performed best.
References
Yefimova VG, Pilipenko TM. Development of the composition of the cosmetic emulsion cream with the application of oil from prayer of grannes and the study of its emulsion properties. Herald of Khmelnytskyi national university. 2019;279(6):80-3. DOI 10.31891/2307-5732-2019-279-6-80-83. Ukrainian
Lutsenko LS, Radziyevska IH, Babenko VI. INVESTIGATION OF THE STABILITY OF COSMETIC EMULSIONS USING A HYDROPHILIC EMULSIFIER. Sci Notes Taurida National V I Vernadsky Univ Ser. DOI 2019:3(2):37-41. Ukrainian DOI: https://doi.org/10.32838/2663-5941/2019.3-2/07
Polova Z, Nehoda T, Butkevych T. Investigation of Oil in Water Emulsion properties depending on the change of Emulsifiers combinations. Res J Pharm Technol. 2023:5603-9. DOI 10.52711/0974-360x.2023.00906. Ukrainian DOI: https://doi.org/10.52711/0974-360X.2023.00906
Solovyov S., Koval AS. Features of the Ukr J Mil Med.2023:4(3):111-22. DOI 10.46847/ujmm.2023.3(4)-111. Ukrainian DOI: https://doi.org/10.46847/ujmm.2023.3(4)-111
Kovalchuk O, Barna O. Prospects for creating a cosmetic product based on the phytosubstance of the herb Siberian statice. XXVIII Congress of students and young scientists "Future in science" (dedicated to the 170th anniversary of the birth of I.Ya. Horbachevsky); 8-10 apr. 2024; Ternopil, Ukraine. Ternopil: I. Horbachevsky TNMU; 2024: 190. Ukrainian
Kopel V. Research on the influence of extraction modes on the degree of extraction of biologically active substances from Siberian statice [master's thesis]. Ternopil: I.Ya. Horbachevsky; 2022. 93 p. Ukrainian
Abilda MM, Kozhanova, KK, Zhusupova, GE. Towards pharmaceutical development of drugs with extract of Siberian statice LIMONIUM GMELINII (WILLD.) O.KUNTZE). Industrial Pharmacy - Realities and Prospects. Kharkiv: 2022. 33 p. Ukrainian
Peshuk LV., Bavika L, Demidov IM. Technology of perfumery and cosmetic products. Kyiv: Center for Educational Literature, 2022. 376 p. Ukrainian
Huang K, Liu R, Zhang Y, Guan X. Characteristics of two cedarwood essential oil emulsions and their antioxidant and antibacterial activities. Food Chem 2021;346:128970. DOI 10.1016/j.foodchem.2020.128970. DOI: https://doi.org/10.1016/j.foodchem.2020.128970
Julio LM, Copado CN, Diehl BW, Tomás MC, Ixtaina VY. Development of chia oil-in-water nanoemulsions using different homogenization technologies and the layer-by-layer technique. Explor Foods Foodomics. 2025:2(2):107-24. DOI 10.37349/eff.2024.00029. DOI: https://doi.org/10.37349/eff.2024.00029
State Pharmacopoeia of Ukraine. State enterprise "Ukrainian Scientific Pharmacopoeia Center for the Quality of Medicinal Products". 2nd ed. Add 1. Kharkiv: State enterprise "Ukrainian Scientific Pharmacopoeial Center for the Quality of Medicines", 2015. P. 354-377.
Biopharmacy: a textbook / edited by: Borysyuk I.Yu., Fizor N.S., Akisheva A.S. Odesa :ONMedU, 2020.98 p. Ukrainian
Fedorovska MI. Biopharmacy: methodological recommendations for laboratory classes: Lutsk: P “Zorya-plus” VOO VOI SOIU, 2022. 30 p. Ukrainian
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