BIOLOGICAL ACTIVITY OF ISOPROPYLAMINE ANTHRAQUINONE
DOI:
https://doi.org/10.11603/2312-0967.2024.2.14820Keywords:
anthraquinones, synthesis, cytotoxicity, SwissAdmeAbstract
The aim of the work. To predict the drug-likeness and toxicity using modern web tools of the isopropylaminoanthraquinone compound, as well as to experimentally prove a possible mechanism of antitumor activity.
Materials and Methods. For the anthraquinone compound, an in silico drug-likeness and toxicity screening was performed using SwissADME and ProTox II online services. Prediction of the antitumor activity mechanism was analyzed using the US National Cancer Institute (NCI) PRISM service.
Results and Discussion. 1-Amino-4-(isopropylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid was synthesized by the reaction of nucleophilic substitution of bromamic acid with isopropylamine, which acted as a nucleoforming agent. The structure of the synthesized derivative (98% yield) was confirmed by 1H, 13C NMR, IR and LC-MS spectra. The studied anthraquinone compound showed satisfactory drug-like characteristics and a low toxicity profile.
Conclusions. The obtained results may become a platform for further structural optimization of the identified compound based on anthraquinone with an isopropylamine fragment in the development of modern anticancer drugs.
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