INVESTIGATION OF ANTI-INFLAMMATORY AND MEMBRANE STABILIZING ACTIVITY OF THE GEL ZHYVITAN
DOI:
https://doi.org/10.11603/2312-0967.2024.2.14760Keywords:
Zhyvitan gel, horse chestnut extract, comfrey extract, antiexudative activity, membrane stabilizing activityAbstract
The aim of the work. To investigate the anti-exudative and membrane-protective activity of Zhyvitan gel and its components.
Materials and Methods. The study was conducted on sexually mature rats. Zhyvitan gel and its active ingredients - horse chestnut extract and comfrey extract were used as the object of study in the prophylactic regimen. The anti-inflammatory activity was studied in a rat model of carrageenan edema. The membrane-protective activity was studied in a model of spontaneous erythrocyte hemolysis.
Results and Discussion. Zhyvitan gel showed the most pronounced antiexudative activity at the end of the experiment at 3-4 hours. The active ingredients - extracts of horse chestnut and comfrey showed moderate anti-exudative activity. Traumel C gel was inferior in anti-inflammatory activity compared to Zhyvitan gel. According to the results of membrane-protective activity, Zhyvitan gel and comfrey extract had the most pronounced effect. Traumel C gel showed a moderate membrane stabilizing effect and was inferior to Zhyvitan gel.
Conclusions. Zhyvitan gel based on the active substances horse chestnut and comfrey extracts has anti-exudative activity due to the ability to reduce carrageenan edema in rats and inhibit the prostaglandin-kinin system. In the model of spontaneous erythrocyte hemolysis in rats, Zhyvitan gel has a pronounced membrane-protective effect. Zhyvitan gel exceeds the reference drug in terms of antiexudative and membrane-protective activity.
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