STUDY OF DEXTROMETHORPHAN EXTRACTION CONDITIONS BY ORGANIC SOLVENTS FROM AQUEOUS SOLUTIONS
DOI:
https://doi.org/10.11603/2312-0967.2023.4.14364Keywords:
dextromethorphan, extraction, organic solvent, salting-out electrolytes, degree of extraction, solution pHAbstract
The aim of the work. To study the extraction conditions (effective extragent, the medium pH, extraneous electrolytes) of dextromethorphan from aqueous solutions.
Materials and Methods. The substance of dextromethorphan hydrobromide was used for the analysis. Chloroform, diethyl ether, hexane, sodium chloride, ammonium sulfate; 0.1 M solutions of hydrochloric acid and sodium hydroxide were used as the reagents. Spectrophotometric measurements were performed on a Lambda-25 spectrophotometer (PerkinElmer, USA), pH of solutions was measured on an AI-123 ionometer.
Results and Discussion. The conditions of dextromethorphan extraction from an aqueous medium (pH 3-12) with various organic solvents were studied. It was established that the highest degree of dextromethorphan extraction (82.64%) is achieved at extraction with chloroform from alkaline aqueous solutions (pH 10). The dextromethorphan extraction from aqueous solution with hexane is observed from pH 5. So hexane as an extragent may be used for cleaning organic extracts, which are obtained in a process of dextromethorphan isolation from biological material. The addition of salting-out electrolytes to the extraction system is accompanied by an increasing of the degree of dextromethorphan extraction from acidic solutions by chloroform, diethyl ether and hexane and does not affect on the efficiency of its extraction from alkaline solutions.
Conclusions. Chloroform is the most effective extragent of dextromethorphan from alkaline aqueous solutions (pH 10). Hexane is recommended for cleaning organic extracts from impurities at a weakly acidic medium (pH 5). The salting-out electrolytes using during the dextromethorphan extraction will be slightly increased the degree of extraction from weakly acidic solutions and will be not affected on the efficiency of extraction from alkaline solutions.
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