EVALUATION OF THE INFLUENCE OF THICK EXTRACT FROM SHIITAKE MUSHROOMS ON THE DEVELOPMENT OF INFLAMMATION PROCESSES UNDER THE CONDITIONS OF TESTOSTERONE-INDUCED PROSTATIC HYPERPLASIA IN RATS
DOI:
https://doi.org/10.11603/2312-0967.2023.3.14169Keywords:
shiitake mushrooms, thick extract, prostatic hyperplasia, prostate-protective effect;, anti-inflammatory effectAbstract
The aim of the work. To evaluate the effect of thick extract from shiitake mushrooms on the development of inflammatory processes in rats with testosterone-induced prostate hyperplasia.
Materials and Methods. Experimental work was performed on 56 white male rats, divided into seven groups. The model of testosterone-induced hyperplasia of the prostate gland was reproduced by subcutaneous administration of testosterone propionate to animals for 21 days at a fixed dose. A thick extract of shiitake mushrooms was administered intragastrically daily in parallel with testosterone solution for 3 weeks at a dose of 150 mg per kilogram of rat body weight. The reference drug "Prostatofit" was administered intragastrically, diluted in a ratio of 1:10, in a dose of 1 ml per 100 g of animal body weight. The effectiveness of the thick extract from shiitake mushrooms in the review of anti-inflammatory action was studied by the following biochemical indicators: the number of leukocytes, ESR, the content of C-reactive protein, interleukin-6, tumor necrosis factor-α, levels of testosterone and dihydrotestosterone in the blood serum of white rats.
Results and Discussion. Administration of testosterone propionate subcutaneously for 21 days causes the occurrence of inflammatory processes in the body of animals, which is confirmed by a significant increase in the number of leukocytes, ESR, the level of C-reactive protein, interleukin-6, tumor necrosis factor-α, as well as the concentration of testosterone and dihydrotestosterone in the blood serum of the affected rats. It was experimentally proven that a thick extract from shiitake mushrooms at a dose of 150 mg/kg of animal body weight reliably reduced ESR, the number of leukocytes, the level of C-reactive protein, interleukin-6, tumor necrosis factor-α, testosterone and dihydrotestosterone.
Conclusions. Shiitake extract showed a prostate-protective effect, reducing the level of inflammatory markers under the conditions of benign prostatic hyperplasia in rats induced by the administration of testosterone propionate.
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