STUDY OF THE RANGE OF MEDICINAL PRODUCTS CONTAINING PROPOLIS ON THE UKRAINIAN PHARMACEUTICAL MARKET

Authors

DOI:

https://doi.org/10.11603/2312-0967.2023.2.14054

Keywords:

beekeeping products, propolis, assortment, biologically active substances

Abstract

The aim of the work. Study of the assortment of medicinal products containing propolis on the Ukrainian pharmaceutical market. 

Materials and Methods. Information search, mathematical and statistical, generalizing methods.

Results and Discussion. Propolis is part of eleven registered medicinal products, which mainly belong to groups D03АХ Medicines for the treatment of wounds and ulcerative lesions. Medicines promoting wound healing (45.5 %) and A01A B11 – Antimicrobial and antiseptic medicines for local use in dentistry (36.4 %). The analysis of medicinal products containing propolis by form of release proved that they are represented by tinctures, sprays for the oral cavity, aerosols, capsules, tablets, ointments and suppositories, sprays for the oral cavity and tinctures prevail – 27.3 % each. It was established that the market of medicinal products containing propolis is formed due to exclusively domestically produced drugs, produced mainly in the form of mono drugs – 72.8 %, 90.9 % of medicinal products include a phenolic hydrophobic drug and propolis as an active pharmaceutical ingredient. The leading place among domestic manufacturers is occupied by LLC Pharmaceutical company «ZDOROVYE», LTD – 27.3 % and JSC «Ctoma» – 18.2 %. On the basis of the conducted studies of registered medicines, it is worth highlighting a low percentage of soft medicines, represented only by ointments. 

 Conclusion. The expediency and perspective of the development and implementation into pharmacy and industrial production of new medicines containing propolis has been confirmed.

Author Biographies

O. M. Hlushchenko, O. Bogomolets National Medical University

PhD (Pharmacy), Associate Professor of the Department of Pharmaceutical and Industrial Technology of Medicines

O. I. Yemelianova, O. Bogomolets National Medical University

PhD (Medicine), Associate Professor of the Department of Pharmacognosy and Botany

References

Kismet K, Ozcan C, Kuru S. Does propolis have any effect on non-alcoholic fatty liver disease? Biomed. Pharmacother. 2017;90: 863-71. DOI: 10.1016/j.biopha.2017.04.062. DOI: https://doi.org/10.1016/j.biopha.2017.04.062

Ruiz Ruiz JC, Pacheco López NA, Rejón Méndez EG. Phenolic Content and Bioactivity as Geographical Classifiers of Propolis from Stingless Bees in Southeastern Mexico. Quezada-Euán JJG. Foods. 2023;28;12(7): 1434. DOI: 10.3390/foods12071434. DOI: https://doi.org/10.3390/foods12071434

Anvarifard P, Ostadrahimi A, Ardalan M. The effects of propolis on pro-oxidant-antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial. Sci Rep. 2023;13(1): 9884. DOI: 10.1038/s41598-023-37033-z.PMID: 37337027 DOI: https://doi.org/10.1038/s41598-023-37033-z

Czarnecki R. Propolis w Apiterapii. Kraków; 2017.

Czarnecki R. Pszczeli pyłek kwiatowy w Apiterapii. Kraków; 2017.

Rojczyk E, Klama-Baryła A, Łabuś W. Historical and modern research on propolis and its application in wound healing and other fields of medicine and contributions by Polish studies. Ethnopharmacol. 2020;262: 113159.

doi: 10.1016/j.jep.2020.113159. Epub 2020 Jul 28. DOI: https://doi.org/10.1016/j.jep.2020.113159

Cristiano da Rosa, Ian Lucas Bueno,Ana Clara Martins Quaresma Healing Potential of Propolis in Skin Wounds Evidenced by Clinical Studies Pharmaceuticals. 2022;15(9): 1143; https://doi.org/10.3390/ph15091143 DOI: https://doi.org/10.3390/ph15091143

Tikhonov OI, Bobro SG. Studyng “Propolis-Gel” pharmacological activity. The Pharma Innovation Journal. 2016;5(6): 26-30.

Khamid K, Pushkar T, Ulyzko S, Salachykly A, Samsonova I. Medicinal properties of propolis and its use by pharmacists. Ahrarnyi visnyk Prychornomoria. 2021;101. https://doi.org/10.37000/abbsl.2021.101.12 . Ukrainain. DOI: https://doi.org/10.37000/abbsl.2021.101.12

Compendium of medicines. URL: https:// compendium.com.ua.

State register of medicines. URL: http://www. drlz.com.ua.

Base of Patents ofUkraine. https://uapatents.com Ukrainian.

Konoshevych LV. Theoretical rationale for improving the technology of propolis eye drops [thesis abstract]. Kharkiv, Ukraine; National University of Pharmacy of the Ministry of Health of Ukraine; 2018. Ukrainian.

Vlasenko IO, Davtian LL, Zaliska O M. Study of pharmaceutical provision of type 2 diabetes therapy in Ukraine. Farm chasop. 2022;2: 12-20. https://doi.org/10.11603/2312-0967.2022.2.13332. Ukrainian. DOI: https://doi.org/10.11603/2312-0967.2022.2.13332

Mujica V, Orrego R, Fuentealba R. Propolis as an adjuvant in the healing of human diabetic foot wounds receiving care in the diagnostic and treatment centre from the regional hospital of Talca. J. Diabetes Res. 2019;2507578. DOI:10.1155/2019/2507578 DOI: https://doi.org/10.1155/2019/2507578

Afkhamizadeh M, Aboutorabi R, Ravari H. Topical propolis improves wound healing in diabetic foot ulcer patients: A randomized controlled trial. Nat Prod Res. 2018;32: 2096-9. DOI:10.1080/14786419.2017.1363755 DOI: https://doi.org/10.1080/14786419.2017.1363755

Silva CR, Baltazar F, Almeida-Aguilar C. Propolis: A complex natural product, with an infinity of biological activities that can be explored for the development of medicines. Evid. - Based Complement Alternat. Med. 2015;2015: 206439. DOI: 10.1155/2015/206439. Epub 2015 May 27. DOI: https://doi.org/10.1155/2015/206439

Yang J, Pi A, Yan L, Li J. Research progress on therapeutic effect and mechanism of propolis on wound healing. Evid. - Based Complement. Alternat. Med. 2022;5798941. https://doi.org/10.1155/2022/5798941 DOI: https://doi.org/10.1155/2022/5798941

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Published

2023-06-30

How to Cite

Hlushchenko, O. M., & Yemelianova, O. I. (2023). STUDY OF THE RANGE OF MEDICINAL PRODUCTS CONTAINING PROPOLIS ON THE UKRAINIAN PHARMACEUTICAL MARKET. Pharmaceutical Review Farmacevtičnij časopis, (2), 31–40. https://doi.org/10.11603/2312-0967.2023.2.14054

Issue

No. 2 (2023)

Section

Pharmaceutical management, marketing and logistics

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