STUDY OF THE FEASIBILITY OF EXPANDING THE RANGE OF MEDICINES BASED ON PARACETAMOL

Authors

DOI:

https://doi.org/10.11603/2312-0967.2023.3.13914

Keywords:

analgesics and antipyretics, medicinal products, marketing analysis, assortment, tablets

Abstract

The aim of the work. To conduct an analysis of medicinal products registered on the pharmaceutical market of Ukraine, which contain paracetamol in their composition.

Materials and Methods. The work is based on information obtained from the "State Register of Medicinal Products of Ukraine" website. The obtained data were processed and systematized using statistical, logical and graphic methods.

Results and Discussion. The pharmaceutical market of Ukraine contains a significant number of medicines with paracetamol and domestic manufacturers represent about 1/3 of its range, at the same time, there is no production of the substance. Paracetamol is known all over the world and has a significant number of dosage forms to cover the greatest possibilities of use in mono or combined composition. So, for example, today the combined compositions of "cold medicine" have gained popularity. However, there are dosage forms that are produced only in monoforms, they include: solution for injections, oral solution, suppositories, almost all suspensions.

Conclusions. On the basis of the review of literary sources and the analysis of the pharmaceutical market, a conclusion was made about the relevance of developing a prolonged form of paracetamol due to the formation of a matrix, which became the basis for further pharmaco-technological research to find the optimal composition of tablets.

Author Biographies

S. I. Trutaev, National University of Pharmacy

PhD (Pharmacy), Associate Professor of the Department of Industrial Technology of Drugs

I. V. Saiko, National University of Pharmacy

PhD (Pharmacy), Associate Professor of the Department of Industrial Technology of Drugs

A. A. Sichkar, National University of Pharmacy

PhD (Pharmacy), Associate Professor of the Department of Industrial Technology of Drugs

A. Lakrami, National University of Pharmacy

student of higher education, Faculty for Foreign Citizens’ Education

References

Zempsky W, Bell J, Mossali VM, Kachroo P, Siddiqui K. Common selfcare indications of pain medications in children. Paediatr Drugs. 2023;25(3): 321-41. DOI: 10.1007/s40272-023-00562-1.

Karłowicz-Bodalska K, Sauer N, Jonderko L, Wiela-Hojeńska A. Over the counter pain medications used by adults: a need for pharmacist intervention. Int J Environ Res Public Health. 2023;20(5): 4505. DOI: 10.3390/ijerph20054505.

FDA Drug Safety Communication: FDA has reviewed possible risks of pain medicine use during pregnancy. FDA official site. 2015 URL: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-has-reviewed-possible-risks-pain-medicine-use-during-pregnancy.

Moungmaithong S, Leung BW, Sahota DS, Wang CC, Leung TY, Poon LC. Assessment of embryo morphology following perinatal exposure to aspirin, ibuprofen and paracetamol using whole embryo culture system. J Matern Fetal Neonatal Med. 2022;35(25): 8786-93. DOI: 10.1080/14767058.2021.2005020.

Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AG, Damoiseaux RA. Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. Cochrane Database Syst Rev. 2016;12(12): CD011534. DOI: 10.1002/14651858.CD011534.pub2.

Abbasi M, Teakell J. Literature review: are NSAIDs harmful and is acetaminophen well tolerated? Curr Opin Nephrol Hypertens. 2023;32(3): 284-9. DOI: 10.1097/MNH.0000000000000886.

State Register of Medicinal Products of Ukraine. Available from: http://www.drlz.com.ua/ibp/ddsite.nsf/all/shlist?opendocument& sklad=%EF%E0%F0%E0%F6%E5%F2%E0%EC%EE%EB

Compendium of medicines. Available from: https://compendium.com.ua/uk/akt/80/2903/paracetamolum/

Darandale AS, Ghule PJ, Aher AA, Narwate BM. Sustained release dosage form: a concise review. International Journal of Pharmaceutics & Drug Analysis. 2017;5(5): 153-160.

Vekatashwaramoorthy N, Sambathkumar R, Subramani M. A novel approach on role of polymers used in sustained release drug delivery system – a review. Saudi Journal of Medical & Pharm. Sciences. 2021;7(4): 170-8. DOI: 10.36348/sjmps.2021.v07i04.002

Tawakkul N, Batool M, Batool S, Mustafa G, Faizan Nazar M. General mechanisms of drug loading and sustained release 4. Novel Platforms for Drug Delivery Applications. 2023;3: 31-57. DOI: 10.1016/B978-0-323-91376-8.00003-3.

Published

2023-09-30

How to Cite

Trutaev, S. I., Saiko, I. V., Sichkar, A. A., & Lakrami, A. (2023). STUDY OF THE FEASIBILITY OF EXPANDING THE RANGE OF MEDICINES BASED ON PARACETAMOL. Pharmaceutical Review Farmacevtičnij časopis, (3), 26–32. https://doi.org/10.11603/2312-0967.2023.3.13914

Issue

Section

Pharmaceutical management, marketing and logistics