STUDY OF DEXTROMETHORPHAN SPECTRAL CHARACTERISTICS
DOI:
https://doi.org/10.11603/2312-0967.2022.3.13341Keywords:
dextromethorphan, UV and IR spectroscopy, molar and specific absorptivityAbstract
The aim of the work. To study the IR and UV absorption spectra of dextromethorphan, to calculate its molar and specific absorptivity in solvents of different polarity.
Materials and Methods. The substance of dextromethorphan hydrobromide was used for the analysis. Cary 50 M and Lambda-25 spectrophotometers were used to record the electronic absorption spectra and measure absorption. Nicolet iS 10FTIR spectrometer was used for IR spectroscopic study of dextromethorphan hydrobromide.
Results and Discussion. We studied the UV spectra of dextromethorphan in solvents of different polarity: ethanol, chloroform, water, hexane, diethyl ether. Our research has shown that the absorption maximum of dextromethorphan in the UV region is ranges from 280 to 282 nm in all solvents. The peculiarity and difference in the spectra in solvents with different polarity is the presence of a smaller or larger expansion-bifurcation in the absorption maximum. The largest values of molar and specific absorptivity are in chloroform (2193 and 80.83, in accordance) and ethanol (2181 and 80.40, in accordance) dextromethorphan solutions. The IR spectra of dextromethorphan was deciphered.
Conclusions. IR and UV absorption spectra of dextromethorphan are obtained and can be further used for its identification and assay. Molar and specific absorptivity was calculated in various solvents. Ethyl alcohol was proved to be a rational solvent for quantitative determination.
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