COMPARATIVE RESEARCH OF SOME BRANDS OF LACTOSE AS FILLERS FOR DIRECT COMPRESSION OF TABLETS
DOI:
https://doi.org/10.11603/2312-0967.2021.2.12056Keywords:
tablets, direct compression, lactose, MicroceLac 100, Ludipress, Cellactose 80, Pharmatose DCL-21Abstract
The aim of the work. Studying of physical and technological characteristics of different brands of lactose and their influence on pharmacological and technological parameters of acetylsalicylic acid tablets and metformin hydrochloride tablets.
Materials and methods. Acetylsalicylic acid and metformin hydrochloride were used as model substances for studying the value of lactose monohydrate, MicroceLac 100, Ludipress, Cellactose 80 and Pharmatose DCL-21 in the technology of direct compression of tablets. The mass for tableting was evaluated by bulk density, tapped density, flowability and Hausner coefficient. The tablets were obtained by direct compression and monitored for such parameters as tablet hardness, disintegration time and friability.
Results and discussion. Physico-technological parameters of the mass for tableting with acetylsalicylic acid were studied. The mass containing Ludipress or Cellactose 80 or Pharmatose DCL-21 has the best flowability and Hausner coefficient. The introduction of Pharmatose DCL-21 or MicroceLac 100 improved tablet hardness and friability. The use of lactose of any type provided rapid disintegration of acetylsalicylic acid tablets. Metformin hydrochloride powder is characterized by unsatisfactory flowability and requires the introduction of rational excipients. The hardness and friability of metformin tablets is significantly improved with the introduction of Cellactose 80 or MicroceLac 100.
Conclusions. The possibility of using lactose monohydrate, MicroceLac 100, Ludipress, Cellactose 80 and Pharmatose DCL-21 in the technology of direct compression was investigated using acetylsalicylic acid tablets and metformin hydrochloride tablets. The influence of the studied lactose brands on the pharmaco-technological parameters of the obtained tablets was studied.
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