IMPROVEMENT OF THE COMPOSITION OF EXTEMPORAL SUSPENSION WITH BISMUTH NITRATE BASIC FOR APPLICATION IN GASTROENTEROLOGY – A THEORETICAL BASIS

Authors

DOI:

https://doi.org/10.11603/2312-0967.2020.4.11541

Keywords:

peptic ulcer, anti-Helicobacter therapy, suspension, bismuth subnitrate, aerosil

Abstract

The aim of the work. Theoretical substantiation of improving the composition of an extemporal suspension with bismuth subnitrate for use in gastroenterology.

Materials and Methods. To search for information, the methods of systemic and comparative analysis and the bibliosemantic method of studying the modern view of the pharmacotherapy of diseases of the gastrointestinal tract, in particular ulcer, and the use of bismuth-containing drugs for their treatment were used.

Results and Discussion. The expediency of using active pharmaceutical ingredients (bismuth subnitrate and aerosil) as part of an extemporal suspension is considered. Analysis of literature sources showed that bismuth subnitrate has anti-inflammatory, bactericidal activity against Helicobacter pylori, as well as a vasoconstrictor effect; aerosil exhibits sorption and bactericidal activity.

Conclusions. The improvement of the composition of the extemporal suspension with bismuth subnitrate for use in gastroenterology has been theoretically substantiated.

Author Biographies

G. M. Melnyk, National University of Pharmacy of the Ministry of Health of Ukraine

PhD (Pharmacy), postdoctoral student of the Technology of Drugs Department

T. G. Yarnykh, National University of Pharmacy of the Ministry of Health of Ukraine

DSc (Pharmacy), Professor, Head of the Technology of Drugs Department

G. B. Yuryeva, National University of Pharmacy of the Ministry of Health of Ukraine

PhD (Pharmacy), Associate Professor of the Technology of Drugs Department

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Published

2020-11-30

How to Cite

Melnyk, G. M., Yarnykh, T. G., & Yuryeva, G. B. (2020). IMPROVEMENT OF THE COMPOSITION OF EXTEMPORAL SUSPENSION WITH BISMUTH NITRATE BASIC FOR APPLICATION IN GASTROENTEROLOGY – A THEORETICAL BASIS. Pharmaceutical Review Farmacevtičnij časopis, (4), 25–30. https://doi.org/10.11603/2312-0967.2020.4.11541

Issue

No. 4 (2020)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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