EXPERIMENTAL STUDIES ON THE CREATION OF A NEW DRUG WITH A DRY EXTRACT OF SCUTELLARIA BAICALENSIS

Authors

DOI:

https://doi.org/10.11603/2312-0967.2020.1.10976

Keywords:

emulgel, dry extract, rheology, Scutellaria baicalensis

Abstract

The aim of the study. To carry out research on the development of an emulgel with a dry extract of Scutellaria baicalensis, select the optimal gelling agent, emulsifier and oil content. To study the rheological indicators.

Materials and Methods. The structural-mechanical (rheological) properties of gel bases and samples were studied using a Rheotest-2 rotational viscometer (Germany) with coaxial cylinders. The selection of the oil phase content was carried out using the method of optical microscopy. The degree of dispersion and determination of the linear particle sizes of the emulgel was carried out using a Conus Academy electron microscope with an integrated camera. To study the rheoparameters, mechanical stability indices were calculated.

Results and Discussion. As a result of the studies, a rational gelling agent (carbopol Ultrez 10 NF) and the concentration of the Prolipid 141TM emulsifier were selected, the oil phase content was determined, and a study of rheological properties and mechanical stability have been carried out.

Conclusions. Ultrez 10 NF (1.5%) as a gelling agent, corn oil (20 %) as an oil phase, Prolipid 141TM (3%) as an emulsifier were chosen. It has been proved that the resulting emulgel is a structured system with a plastic type of flow.

Author Biographies

G. D. Slipchenko, National University of Pharmacy

PhD (Pharmacy), Associate Professor of the Department of the Drugs Industrial Technology

O. A. Ruban, National University of Pharmacy

DS (Pharmacy), Head of the Department of the Drugs Industrial Technology

References

Pertsev IM, Dmitrievsky DI, Rybachuk VD Excipients in drug technology: impact on technological, consumer, economic characteristics and therapeutic efficacy. [Допоміжні речовини в технології ліків: вплив на технологічні, споживчі, економічні характеристики і терапевтичну ефективність] Kharkiv: Golden Pages, 2010. Ukrainian.

Lyapunov AM, Bezugla OP, Libina VV, Andrianov TV [A study of soft drugs with mometasone furoate on emulsion bases] Ukrainian Biopharmaceutical Journal. 2017;6(53): 9-18. Ukrainian. doi: 10.24959/ubphj.17.145 DOI: https://doi.org/10.24959/ubphj.17.145

Malkin AYa., Isaev AI Rheology: concepts, methods, applications [Реология: концепции, методы, приложения].St. Petersburg: Profession; 2007. Russian.

Iroko Imamuzo Matthew, Khokhlenkova NV, Stolper Yu. M / Choosing the base - carrier of the Aloe - Dental gel for application in dentistry. Social pharmacy. Vol. 2.2. 2016. Available from: http://nbuv.gov.ua/UJRN/sphhc_2016_2_2_6. Ukrainian DOI: https://doi.org/10.24959/sphhcj.16.44

Lyapunov NA Bezuglai E P, Zinchenko I A, Lyapunov A N., Stolper Y. M [Soft drugs: pharmaceutical development and technology transfer]. Pharmaceutical industry. Available from: https://promvit.com.ua/wp-content/uploads/2014/11/tema_PharmOtr0546-3.pdf. Ukrainian.

Pulyaev DS, Kovalevskaya IV, Chueshov VI, [Substantiation of carbomer concentration in the Algozan gel composition. News of Pharmacy. 2010;2(62): 22-5. Ukrainian.

Romanko TV [Rheological properties of the original pharmaceutical composition of a nanostructured system of silver stabilized by arabinogalactan]. Chemical and Pharmaceutical Journal. 2013;2:31-34. Russian.

Olennikov DN, Chirikova NK, Tanhaeva LM [The chemical composition of the Scutellaria baicalensis (Scutellaria baicalensis Georgi)]. Chemistry of Vegetable Raw Materials. 2010;2: 77-84. Russian.

Chang HH, Yi PL, Cheng CH, Lu CY, Hsiao YT, Tsai YF. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation J. Ethnopharmacol. 2011;17:135(2): 359-68. doi: 10.1016/j.jep.2011.03.023 DOI: https://doi.org/10.1016/j.jep.2011.03.023

Carbopol® Ultrez 10 Polymer, Technical Data Sheet (TDS-225), Lubrizol : Cleveland. 2002

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Published

2020-03-24

How to Cite

Slipchenko, G. D., & Ruban, O. A. (2020). EXPERIMENTAL STUDIES ON THE CREATION OF A NEW DRUG WITH A DRY EXTRACT OF SCUTELLARIA BAICALENSIS. Pharmaceutical Review Farmacevtičnij časopis, (1), 21–27. https://doi.org/10.11603/2312-0967.2020.1.10976

Issue

No. 1 (2020)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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